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Group 2 Innate Lymphoid Cells Exacerbate Amebic Liver Abscess in Mice
http://hdl.handle.net/10069/40309
http://hdl.handle.net/10069/40309ebaa2d50-2f28-4a14-be00-0b1fca8f6608
名前 / ファイル | ライセンス | アクション |
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iSci23_101544.pdf (5.4 MB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2020-10-06 | |||||
タイトル | ||||||
タイトル | Group 2 Innate Lymphoid Cells Exacerbate Amebic Liver Abscess in Mice | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Immunology | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Microbiology | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Microbiology Parasite | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Nakamura, Risa
× Nakamura, Risa× Yoshizawa, Akihiro× Moriyasu, Taeko× Deloer, Sharmina× Senba, Masachika× Kikuchi, Mihoko× Koyasu, Shigeo× Moro, Kazuyo× Hamano, Shinjiro |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Entamoeba histolytica, a protozoan parasite in the lumen of the human large intestine, occasionally spreads to the liver and induces amebic liver abscesses (ALAs). Upon infection with E. histolytica, high levels of type 2 cytokines are induced in the liver early after infection. However, the sources and functions of these initial type 2 cytokines in ALA formation remain unclear. In this study, we examined the roles of group 2 innate lymphoid cells (ILC2s) in ALA formation. Hepatic ILC2 numbers were significantly increased and they produced robust levels of IL-5. The in vivo transfer of ILC2s into Rag2?/?common γ chain (γc)?/? KO mice aggravated ALA formation accompanied by eosinophilia and neutrophilia. Furthermore, IL-33-deficient mice and IL-5-neutralized mice had less ALA formations. These results suggest that ILC2s contribute to exacerbating the pathogenesis of ALA by producing early type 2 cytokines and promoting the accumulation of eosinophils and neutrophils in the liver. |
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書誌情報 |
iScience 巻 23, 号 9, p. 101544, 発行日 2020-09-25 |
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出版者 | ||||||
出版者 | Cell Press | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 25890042 | |||||
DOI | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1016/j.isci.2020.101544 | |||||
権利 | ||||||
権利情報 | c2020 The Authors. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/) | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | iScience, 23 (9), art.no.101544; 2020 |