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Stimulation of Osteogenesis in Bone Defects Implanted with Biodegradable Hydroxyapatite Composed of Rod-Shaped Particles under Mechanical Unloading
http://hdl.handle.net/10069/31012
http://hdl.handle.net/10069/31012986dba21-89d4-4649-a0fe-ca3841cd98d0
名前 / ファイル | ライセンス | アクション |
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AHC45_283.pdf (1.7 MB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2013-03-15 | |||||
タイトル | ||||||
タイトル | Stimulation of Osteogenesis in Bone Defects Implanted with Biodegradable Hydroxyapatite Composed of Rod-Shaped Particles under Mechanical Unloading | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Beta-tricalcium phosphate | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Bone metabolism | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Bone substitute | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Hydroxyapatite | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Mechanical unloading | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Ikeda, Tohru
× Ikeda, Tohru× Gonda, Yoshinori× Tatsukawa, Eri× Shibata, Yasuaki× Kamitakahara, Masanobu× Okuda, Takatoshi× Yonezawa, Ikuho× Kurosawa, Hisashi× Ioku, Koji |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | The aim of thisSstudy was totevaluatertheninfluence of mechanical unloading on the repair of bone defects with implantation of biodegradable bone substitutes. Spherical granules of biodegradable hydroxyapatite composed of rod-shaped particles (RHA) or beta-tricalcium phosphate composed of rod-shaped particles (RTCP) were implanted into a bone defect created in the distal end of the right femur of 8-week-old Wistar rats. Two, 6, 10, and 22 weeks after implantation, part of the sciatic nerve in the thigh was resected and exposed to mechanical unloading for 2 weeks. Then, 4, 8, 12 and 24 weeks after implantation, repair of the bone defect was analyzed. As a control, the bone defect without implantation of ceramic granules was also analyzed. Both RHA and RTCP tended to be reduced, but the reduction was not obvious during the experimental period. At 12 and 24 weeks after implantation, the amount of newly formed bone in the animal implanted with RHA was significantly greater than that at 4 weeks after implantation, but that in the animal implanted with RTCP or without implantation was not significantly different. The number of osteoclasts in the region implanted with RHA was significantly larger than that of the region implanted with RTCP or without implantation at 12 and 24 weeks. The activities of alkaline phosphatase in osteoblasts and tartrate-resistant acid phosphatase in osteoclasts were remarkably increased in the bone defects with implantation compared with those in the bone defects without implantation. These results suggested that RHA stimulated osteogenesis and osteoclastogenesis even after 2 weeks of mechanical unloading, and that RHA could be expected to improve the repair of bone defects in patients under the condition of skeletal unloading. | |||||
書誌情報 |
ACTA HISTOCHEMICA ET CYTOCHEMICA 巻 45, 号 5, p. 283-292, 発行日 2012-10-31 |
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出版者 | ||||||
出版者 | 日本組織細胞化学会 | |||||
出版者別言語 | ||||||
Japan Society of Histochemistry and Cytochemistry | ||||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 00445991 | |||||
EISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 13475800 | |||||
DOI | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1267/ahc.12012 | |||||
権利 | ||||||
権利情報 | © 2012 By the Japan Society of Histochemistry and Cytochemistry | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | ACTA HISTOCHEMICA ET CYTOCHEMICA, 45(5), pp.283-292; 2012 |