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Novel Powdered Anti-adhesion Material: Preventing Postoperative Intra-abdominal Adhesions in a Rat Model
http://hdl.handle.net/10069/31770
http://hdl.handle.net/10069/317704c9cb676-04bb-44a6-bbcf-e66a78c65dc1
名前 / ファイル | ライセンス | アクション |
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IJMS10_467.pdf (1.2 MB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2013-05-15 | |||||
タイトル | ||||||
タイトル | Novel Powdered Anti-adhesion Material: Preventing Postoperative Intra-abdominal Adhesions in a Rat Model | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Adhesion prevention | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Anti-adhesion materials | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Biodegradable material | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Powder | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Rat model | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Takagi, Katsunori
× Takagi, Katsunori× Araki, Masato× Fukuoka, Hidetoshi× Takeshita, Hiroaki× Hidaka, Shigekazu× Nanashima, Atsushi× Sawai, Terumitsu× Nagayasu, Takeshi× Hyon, Suong-Hyu× Nakajima, Naoki |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Background: Although laparoscopic surgery has decreased postoperative adhesions, complications induced by adhesions are still of great concern. The aim of this study was to investigate the anti-adhesive effects of a novel powdered anti-adhesion material that can be applied during laparoscopic surgery in comparison with other anti-adhesion materials. Methods: Our novel powdered anti-adhesion material is composed of aldehyde dextran and ε-poly(L-lysine). In 40 male rats, a 2.5×2.0-cm abdominal wall resection and cecum abrasion were performed. The rats were randomized into four groups based on the anti-adhesion treatments: normal saline; Seprafilm® Interceed® and novel powdered anti-adhesion material. The animals were euthanized on days 7 and 28 to evaluate the adhesion severity, area of adhesion formation, gross appearance, and pathological changes. Results: The adhesion severities on both days 7 and 28 were significantly lower for all anti-adhesion material groups compared with the normal saline group (p<0.05). Pathologically, all groups showed inflammatory cell infiltration on day 7 and complete regeneration of the peritoneum on day 28. Conclusions: Our novel powdered anti-adhesion material was found to be effective for reducing postoperative intra-abdominal adhesions and showed equivalent efficacy to commercial anti-adhesion materials. | |||||
書誌情報 |
International Journal of Medical Sciences 巻 10, 号 4, p. 467-474, 発行日 2013-03-05 |
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出版者 | ||||||
出版者 | Ivyspring International Publisher | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 14491907 | |||||
DOI | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.7150/ijms.5607 | |||||
権利 | ||||||
権利情報 | © Ivyspring International Publisher. This is an open-access article distributed under the terms of the Creative Commons License (http://creativecommons.org/ licenses/by-nc-nd/3.0/). Reproduction is permitted for personal, noncommercial use, provided that the article is in whole, unmodified, and properly cited. | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | International Journal of Medical Sciences, 10(4), pp.467-474; 2013 |