Cancer treatments have improved significantly during the last decade but are not yet satisfactory. Combination therapy is often administered to improve efficacy and safety. Drug delivery systems can also improve efficacy and safety. To control the spatiotemporal distribution of drugs, nanotechnology involving liposomes, solid lipid nanoparticles, and polymeric micelles has been developed. Co-delivery systems of multiple drugs are a promising approach to combat cancer. Synergistic effects and reduced side effects are expected from the use of co-delivery systems. In this review, we summarize various co-delivery systems for multiple drugs, including small-molecule drugs, nucleic acids, genes, and proteins. Co-delivery of drugs with different properties is relatively difficult, but some researchers have succeeded in developing such co-delivery systems. Environment-responsive carrier designs can control the release of cargos. Although their preparation is more complicated than that of mono-delivery systems, co-delivery systems can simplify clinical procedures and improve patient QOL.
雑誌名
Chemical and Pharmaceutical Bulletin
巻
68
号
7
ページ
603 - 612
発行年
2020-07-01
出版者
日本薬学会
出版者別言語
Pharmaceutical Society of Japan
ISSN
00092363
EISSN
1347-5223
DOI
10.1248/cpb.c20-00008
権利
c 2020 The Pharmaceutical Society of Japan
著者版フラグ
publisher
引用
Chemical & pharmaceutical bulletin, 68(7), pp.603-612; 2020
Co-delivery Systems of Multiple Drugs Using Nanotechnology for Future Cancer Therapy
CPBul68_603.pdf
(666.37KB)
NAOSITEについて