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Protective Role of Interferon Regulatory Factor 3-Mediated Signaling against Prion Infection
http://hdl.handle.net/10069/30199
http://hdl.handle.net/10069/301996d8644b5-193e-485e-9433-5de9f18e9ea6
名前 / ファイル | ライセンス | アクション |
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JV86_4947.pdf (811.6 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2013-01-09 | |||||
タイトル | ||||||
タイトル | Protective Role of Interferon Regulatory Factor 3-Mediated Signaling against Prion Infection | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | interferon regulatory factor 3 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | prion protein | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | small interfering RNA | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | animal cell | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | animal experiment | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | animal model | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | animal tissue | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | article | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | bovine spongiform encephalopathy | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | cell culture | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | controlled study | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | immunopathogenesis | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | innate immunity | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | mouse | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | neuroprotection | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | nonhuman | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | nucleotide sequence | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | prion disease | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | priority journal | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | signal transduction | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | virus transmission | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | wild type | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Brain | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Cell Line | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Interferon Regulatory Factor-3 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Mice | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Mice, Inbred C57BL | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Mice, Knockout | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Prion Diseases | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | PrPSc Proteins | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Signal Transduction | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Spleen | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Ishibashi, Daisuke
× Ishibashi, Daisuke× Atarashi, Ryuichiro× Fuse, Takayuki× Nakagaki, Takehiro× Yamaguchi, Naohiro× Satoh, Katsuya× Honda, Kenya× Nishida, Noriyuki |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Abnormal prion protein (PrP Sc) generated from the cellular isoform of PrP (PrP C) is assumed to be the main or sole component of the pathogen, called prion, of transmissible spongiform encephalopathies (TSE). Because PrP is a host-encoded protein, acquired immune responses are not induced in TSE. Meanwhile, activation of the innate immune system has been suggested to partially block the progression of TSE; however, the mechanism is not well understood. To further elucidate the role of the innate immune system in prion infection, we investigated the function of interferon regulatory factor 3 (IRF3), a key transcription factor of the MyD88-independent type I interferon (IFN) production pathway. We found that IRF3-deficient mice exhibited significantly earlier onset with three murine TSE strains, namely, 22L, FK-1, and murine bovine spongiform encephalopathy (mBSE), following intraperitoneal transmission, than with wild-type controls. Moreover, overexpression of IRF3 attenuated prion infection in the cell culture system, while PrP Sc was increased in prion-infected cells treated with small interfering RNAs (siRNAs) against IRF3, suggesting that IRF3 negatively regulates PrP Sc formation. Our findings provide new insight into the role of the host innate immune system in the pathogenesis of prion diseases. | |||||
書誌情報 |
Journal of Virology 巻 86, 号 9, p. 4947-4955, 発行日 2012-05 |
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出版者 | ||||||
出版者 | American Society for Microbiology | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 0022538X | |||||
DOI | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1128/JVI.06326-11 | |||||
権利 | ||||||
権利情報 | © 2012, American Society for Microbiology. | |||||
著者版フラグ | ||||||
出版タイプ | AM | |||||
出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Journal of Virology, 86(9), pp.4947-4955; 2012 |