WEKO3
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The purpose of this study is to analyze the relationships, between signaling by PEGylated IFN in human hepatocytes, with regard to hepatocyte proliferation, and immunosuppressive drugs in vitro. Methods: Experiment 1 - Normal human hepatocytes (NhHeps) were cultured with/without recombinant human hepatocyte growth factor (r-hHGF) for 48 h, and then treated with 100 IU/mL IFN at the indicated time. The expressions of double-stranded RNA-dependent protein kinase (PKR) and IFN- α-induced antiviral protein were analyzed using Western blotting for the extracted lysates from these cells. Experiment 2 - The NhHeps were cultured in 10% medium containing varying concentrations of tacrolims (Tac), cyclosporine A (CyA), and methylprednisolone (PLS), and the cells were treated with 100 IU/mL IFN at the indicated time. Subsequently, the density of PKR was examined. Results: The expression of PKR was enhanced by HGF. PKR induction by IFN was suppressed by Tac \u003e CyA \u003e PLS. 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Hepatocyte growth factor upregulates interferon signaling in human hepatocytes: Possible implications for interferon therapy after liver transplantation
http://hdl.handle.net/10069/30223
http://hdl.handle.net/10069/302235a583364-a23f-4946-8b5c-345159f93b1c
名前 / ファイル | ライセンス | アクション |
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IMAS3_5.pdf (359.6 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2013-01-11 | |||||
タイトル | ||||||
タイトル | Hepatocyte growth factor upregulates interferon signaling in human hepatocytes: Possible implications for interferon therapy after liver transplantation | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | antiviral therapy | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | HCV infection | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | immunosuppressive drugs | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | liver regeneration | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Hamasaki, Koji
× Hamasaki, Koji× Eguchi, Susumu× Ichikawa, Tatsuki× Takatsuki, Mitsuhisa× Hidaka, Masaaki× Yamanouchi, Kosho× Miyazaki, Kensuke× Inokuma, Takamitsu× Kanematsu, Takashi |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Background/Aim: Although a recurrent hepatitis C virus (HCV) infection is the leading cause of graft loss in liver transplant recipients, the optimal timing to begin interferon (IFN) therapy after LTx is still unknown. The purpose of this study is to analyze the relationships, between signaling by PEGylated IFN in human hepatocytes, with regard to hepatocyte proliferation, and immunosuppressive drugs in vitro. Methods: Experiment 1 - Normal human hepatocytes (NhHeps) were cultured with/without recombinant human hepatocyte growth factor (r-hHGF) for 48 h, and then treated with 100 IU/mL IFN at the indicated time. The expressions of double-stranded RNA-dependent protein kinase (PKR) and IFN- α-induced antiviral protein were analyzed using Western blotting for the extracted lysates from these cells. Experiment 2 - The NhHeps were cultured in 10% medium containing varying concentrations of tacrolims (Tac), cyclosporine A (CyA), and methylprednisolone (PLS), and the cells were treated with 100 IU/mL IFN at the indicated time. Subsequently, the density of PKR was examined. Results: The expression of PKR was enhanced by HGF. PKR induction by IFN was suppressed by Tac > CyA > PLS. Conclusion: Hepatocyte proliferation induced by HGF did not interfere with the signaling by IFN. The presence of immunosuppressive drugs was therefore found to negatively affect IFN signaling. | |||||
書誌情報 |
Interventional Medicine & Applied Science 巻 3, 号 1, p. 5-8, 発行日 2011-03-01 |
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出版者 | ||||||
出版者 | Akadémiai Kiadó | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 20611617 | |||||
EISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 20615094 | |||||
DOI | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1556/IMAS.3.2011.1.2 | |||||
権利 | ||||||
権利情報 | © 2011 Akadémiai Kiadó, Budapest. | |||||
権利 | ||||||
権利情報 | This article is published with open access at Akadémiai Kiadó. | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Interventional Medicine & Applied Science, 3(1), pp.5-8; 2011 |