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Expression of angiotensin II type 1 receptor in rat bladder smooth muscle cells in response to a streptzotocin induced diabetes mellitus model
http://hdl.handle.net/10069/30707
http://hdl.handle.net/10069/30707e02c6fdf-6063-4731-9a32-9005628e5687
名前 / ファイル | ライセンス | アクション |
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CurUro6_62.pdf (880.4 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2013-02-19 | |||||
タイトル | ||||||
タイトル | Expression of angiotensin II type 1 receptor in rat bladder smooth muscle cells in response to a streptzotocin induced diabetes mellitus model | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Angiotensin receptor | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Bladder | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Diabetes mellitus | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Renin-angiotensin system | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Tobu, Shohei
× Tobu, Shohei× Noguchi, Mitsuru× Hatada, Teppei× Mori, Ken-ichi× Matsuo, Manabu× Sakai, Hideki |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Introduction: The aim of this study was to investigate angiotensin II type 1 (AT1) receptors in rat bladder smooth muscle cells and alterations of AT1 receptors by diabetes mellitus and diuretic states. Materials and Methods: Diabetes and diuresis were induced in adult female rats by a single intraperitoneal injection of streptozotocin and feeding 5% sucrose in water. Cystometry was performed on control, diuretic, and diabetic rats at 2 and 8 weeks after treatment. Immunohistochemical staining was used to detect expression of AT1 receptors in the bladder smooth muscle cell membrane. Results and Conclusions: In diabetic rats, expression of AT1 receptors in the bladder smooth muscle cell membrane increased at 2 weeks and further increased at 8 weeks. The local renin-angiotensin system in the rat bladder might be activated by the continuous hyperglycemia caused by intraperitoneal injection of streptozotocin administration. | |||||
書誌情報 |
Current Urology 巻 6, 号 2, p. 62-66, 発行日 2012-09 |
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出版者 | ||||||
出版者 | S. Karger AG | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 16617649 | |||||
EISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 16617657 | |||||
DOI | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1159/000343510 | |||||
権利 | ||||||
権利情報 | © 2012 S. Karger AG, Basel. | |||||
著者版フラグ | ||||||
出版タイプ | AM | |||||
出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Current Urology, 6(2), pp.62-66; 2012 |