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Dipeptidyl-peptidases: Key enzymes producing entry forms of extracellular proteins in asaccharolytic periodontopathic bacterium Porphyromonas gingivalis
http://hdl.handle.net/10069/40331
http://hdl.handle.net/10069/4033138cd27f3-5834-492e-9068-21c4cc7b4d7c
名前 / ファイル | ライセンス | アクション |
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MOM_Nemoto2020.pdf (746.2 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2020-10-16 | |||||
タイトル | ||||||
タイトル | Dipeptidyl-peptidases: Key enzymes producing entry forms of extracellular proteins in asaccharolytic periodontopathic bacterium Porphyromonas gingivalis | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | diabetes mellitus | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | exopeptidase | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | oligopeptide transporter | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | periodontal disease | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | acylpeptidyl-oligopeptidase | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | oligopeptide transporter | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Nemoto, Takayuki K.
× Nemoto, Takayuki K.× Ohara, Nemoto Yuko |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Porphyromonas gingivalis, a pathogen of chronic periodontitis, is an asaccharolytic microorganism that solely utilizes nutritional amino acids as its energy source and cellular constituents. The bacterium is considered to incorporate proteinaceous nutrients mainly as dipeptides, thus exopeptidases that produce dipeptides from polypeptides are critical for survival and proliferation. We present here an overview of dipeptide production by P. gingivalis mediated by dipeptidyl-peptidases (DPPs), e.g., DPP4, DPP5, DPP7, and DPP11, serine exopeptidases localized in periplasm, which release dipeptides from the N-terminus of polypeptides. Additionally, two other exopeptidases, acylpeptidyl-oligopeptidase (AOP) and prolyl tripeptidyl-peptidase A (PTP-A), which liberate N-terminal acylated di-/tri-peptides and tripeptides with Pro at the third position, respectively, provide polypeptides in an acceptable form for DPPs. Hence, a large fraction of dipeptides is produced from nutritional polypeptides by DPPs with differential specificities in combination with AOP and PTP-A. The resultant dipeptides are then incorporated across the inner membrane mainly via a proton-dependent oligopeptide transporter (POT), a member of the major facilitator superfamily. Recent studies also indicate that DPP4 and DPP7 directly link between periodontal and systemic diseases, such as type 2 diabetes mellitus and coagulation abnormality, respectively. Therefore, these dipeptide-producing and incorporation molecules are considered to be potent targets for prevention and treatment of periodontal and related systemic diseases. | |||||
書誌情報 |
Molecular Oral Microbiology 巻 36, 号 2, p. 145-156, 発行日 2020-10-02 |
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出版者 | ||||||
出版者 | John Wiley & Sons Ltd | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 20411006 | |||||
EISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 20411014 | |||||
DOI | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1111/omi.12317 | |||||
権利 | ||||||
権利情報 | c 2020 The Authors. Molecular Oral Microbiology published by John Wiley & Sons Ltd. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Molecular Oral Microbiology, 36(2), pp. 145-156; 2021 |