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Therefore, supplemental oxygen is administered to prevent severe postoperative early hypoxemia. However, a high concentration of oxygen increases the likelihood of secondary complications, such as carbon dioxide (CO2) narcosis.\n Nasal high-flow (NHF) therapy generates high flows (?60?L/min) of heated and humidified gas delivered via nasal cannula and provides respiratory support by generating positive airway pressure, clearance of dead space and reduction of work of breathing. This study aims to determine whether the postoperative hypoxemia and hypercapnia can be prevented by NHF without the requirement \nof supplemental oxygen. The study will recruit adult patients undergoing planned oral surgery under general anesthesia \nat Nagasaki University Hospital. It is a randomized parallel group comparative study with 3 groups: NHF with room air only and no supplemental oxygen, no respiratory support, and face mask oxygen administration. 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A study on respiratory management in acute postoperative period by nasal high flow for patients undergoing surgery under general anesthesia
http://hdl.handle.net/10069/40228
http://hdl.handle.net/10069/40228b1eb5069-1a27-43fd-ab73-7415ef9cc443
名前 / ファイル | ライセンス | アクション |
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Medicine99_21537.pdf (231.6 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2020-08-28 | |||||
タイトル | ||||||
タイトル | A study on respiratory management in acute postoperative period by nasal high flow for patients undergoing surgery under general anesthesia | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | nasal high flow | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | postoperative acute period | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | postoperative hypercapnia | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | postoperative hypoxemia | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Kurata, Shinji
× Kurata, Shinji× Mishima, Gaku× Sekino, Motohiro× Sato, Shuntaro× Pinkham, Maximilian× Tatkov, Stanislav× Ayuse, Takao |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | In head and neck surgery where the oropharyngeal area is the operative field, postoperative respiratory depression and upper airway obstruction are common. Therefore, supplemental oxygen is administered to prevent severe postoperative early hypoxemia. However, a high concentration of oxygen increases the likelihood of secondary complications, such as carbon dioxide (CO2) narcosis. Nasal high-flow (NHF) therapy generates high flows (?60?L/min) of heated and humidified gas delivered via nasal cannula and provides respiratory support by generating positive airway pressure, clearance of dead space and reduction of work of breathing. This study aims to determine whether the postoperative hypoxemia and hypercapnia can be prevented by NHF without the requirement of supplemental oxygen. The study will recruit adult patients undergoing planned oral surgery under general anesthesia at Nagasaki University Hospital. It is a randomized parallel group comparative study with 3 groups: NHF with room air only and no supplemental oxygen, no respiratory support, and face mask oxygen administration. The study protocol will begin at the time that the patient is returned to the general ward and will finish 3?hours later. The primary endpoint is the time-weighted average of transcutaneous O2 over the 180 minutes and secondary endpoints are the time-weighted average of transcutaneous CO2 (tcpCO2), SpO2, and respiratory rate, incidence rate of marked hypercapnia (tcpCO2 ?60 mm Hg for 5 minutes or longer), incidence rate of moderate hypercapnia (tcpCO2 ?50 mm Hg for 5 minutes or longer) and the percentage of time that SpO2 is <90%. Included also is a group in which the postoperative management is performed only by spontaneous breathing without performing respiratory support such as oxygen administration, to investigate the efficacy and necessity of conventional oxygen administration. This exploratory study will investigate the use of NHF without supplemental oxygen as an effective respiratory support during the acute postoperative period. TRIAL REGISTRATION:: The study was registered the jRCTs072200018. URL https://jrct.niph.go.jp/latest-detail/jRCTs072200018. |
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書誌情報 |
Medicine 巻 99, 号 31, p. e21537, 発行日 2020-07-31 |
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出版者 | ||||||
出版者 | Wolters Klwer Health Inc. | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 00257974 | |||||
EISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 15365964 | |||||
DOI | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1097/MD.0000000000021537 | |||||
権利 | ||||||
権利情報 | c 2020 the Author(s). Published by Wolters Kluwer Health, Inc. This is an open access article distributed under the Creative Commons Attribution License 4.0 (CCBY), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Medicine, 99(31), e21537; 2020 |