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Protein Reporter Bioassay Systems for the Phenotypic Screening of Candidate Drugs: A Mouse Platform for Anti-Aging Drug Screening
http://hdl.handle.net/10069/28914
http://hdl.handle.net/10069/28914d8553669-7233-47a5-af63-339ff6062fe4
名前 / ファイル | ライセンス | アクション |
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Sensors12_1648.pdf (171.7 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2012-08-02 | |||||
タイトル | ||||||
タイトル | Protein Reporter Bioassay Systems for the Phenotypic Screening of Candidate Drugs: A Mouse Platform for Anti-Aging Drug Screening | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Age-related disorders | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Drug development | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | High throughput screening | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Reporter mice | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Chiba, Takuya
× Chiba, Takuya× Tsuchiya, Tomoshi× Mori, Ryoichi× Shimokawa, Isao |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Recent drug discovery efforts have utilized high throughput screening (HTS) of large chemical libraries to identify compounds that modify the activity of discrete molecular targets. The molecular target approach to drug screening is widely used in the pharmaceutical and biotechnology industries, because of the amount of knowledge now available regarding protein structure that has been obtained by computer simulation. The molecular target approach requires that the structure of target molecules, and an understanding of their physiological functions, is known. This approach to drug discovery may, however, limit the identification of novel drugs. As an alternative, the phenotypic- or pathway-screening approach to drug discovery is gaining popularity, particularly in the academic sector. This approach not only provides the opportunity to identify promising drug candidates, but also enables novel information regarding biological pathways to be unveiled. Reporter assays are a powerful tool for the phenotypic screening of compound libraries. Of the various reporter genes that can be used in such assays, those encoding secreted proteins enable the screening of hit molecules in both living cells and animals. Cell- and animal-based screens enable simultaneous evaluation of drug metabolism or toxicity with biological activity. Therefore, drug candidates identified in these screens may have increased biological efficacy and a lower risk of side effects in humans. In this article, we review the reporter bioassay systems available for phenotypic drug discovery. | |||||
書誌情報 |
Sensors 巻 12, 号 2, p. 1648-1656, 発行日 2012-02-07 |
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出版者 | ||||||
出版者 | Molecular Diversity Preservation International | |||||
EISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 14248220 | |||||
DOI | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.3390/s120201648 | |||||
権利 | ||||||
権利情報 | © 2012 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/). |
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著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Sensors, 12(2), pp.1648-1656; 2012 |