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Akirin links twist-regulated transcription with the brahma chromatin remodeling complex during embryogenesis
http://hdl.handle.net/10069/29077
http://hdl.handle.net/10069/29077383e1802-5437-4e7d-9614-1a16cc5c6e10
名前 / ファイル | ライセンス | アクション |
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PLoSGen8_1002547.pdf (5.0 MB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2012-08-27 | |||||
タイトル | ||||||
タイトル | Akirin links twist-regulated transcription with the brahma chromatin remodeling complex during embryogenesis | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Nowak, Scott J.
× Nowak, Scott J.× Aihara, Hitoshi× Gonzalez, Katie× Nibu, Yutaka× Baylies, Mary K. |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | The activities of developmentally critical transcription factors are regulated via interactions with cofactors. Such interactions influence transcription factor activity either directly through protein-protein interactions or indirectly by altering the local chromatin environment. Using a yeast double-interaction screen, we identified a highly conserved nuclear protein, Akirin, as a novel cofactor of the key Drosophila melanogaster mesoderm and muscle transcription factor Twist. We find that Akirin interacts genetically and physically with Twist to facilitate expression of some, but not all, Twist-regulated genes during embryonic myogenesis. akirin mutant embryos have muscle defects consistent with altered regulation of a subset of Twist-regulated genes. To regulate transcription, Akirin colocalizes and genetically interacts with subunits of the Brahma SWI/SNF-class chromatin remodeling complex. Our results suggest that, mechanistically, Akirin mediates a novel connection between Twist and a chromatin remodeling complex to facilitate changes in the chromatin environment, leading to the optimal expression of some Twist-regulated genes during Drosophila myogenesis. We propose that this Akirin-mediated link between transcription factors and the Brahma complex represents a novel paradigm for providing tissue and target specificity for transcription factor interactions with the chromatin remodeling machinery. | |||||
書誌情報 |
PLoS Genetics 巻 8, 号 3, p. e1002547, 発行日 2012-03-01 |
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出版者 | ||||||
出版者 | Public Library of Science | |||||
EISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 15537404 | |||||
DOI | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1371/journal.pgen.1002547 | |||||
権利 | ||||||
権利情報 | © 2012 Nowak et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | PLoS Genetics, 8(3), e1002547; 2012 |