WEKO3
アイテム
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We aimed to clarify the differences in the clinical and genetic characteristics of APS3v patients and T1D patients without AITD [T1D/AITD(-)] in the Japanese population. Design/Patients: Our subjects were 54 APS3v patients and 143 T1D/AITD(-) patients who were consecutively diagnosed at Nagasaki University Hospital from 1983 to the present. Results: A remarkable female predominance, a slow and older age onset of T1D, and a higher prevalence of glutamic acid decarboxylase autoantibodies were observed in APS3v patients compared to T1D/AITD(-) patients. The older onset age of T1D in APS3v patients was associated with a higher proportion of slow-onset T1D. Among the two major susceptible human leukocyte antigen (HLA) class II haplotypes in Japanese T1D, DRB1*0405- DQB1*0401, but not DRB1*0901-DQB1*0303, was associated with APS3v patients. Furthermore, DRB1*0803-DQB1*0601 was not protective in patients with APS3v. 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Clinical and genetic characteristics of autoimmune polyglandular syndrome type 3 variant in the Japanese population
http://hdl.handle.net/10069/29379
http://hdl.handle.net/10069/293791c5d2a93-bd62-42eb-a97a-7a9402d9f253
名前 / ファイル | ライセンス | アクション |
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JCEM97_1043.pdf (189.4 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2013-07-01 | |||||
タイトル | ||||||
タイトル | Clinical and genetic characteristics of autoimmune polyglandular syndrome type 3 variant in the Japanese population | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | autoantibody | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | cytotoxic T lymphocyte antigen 4 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | glutamate decarboxylase antibody | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | HLA DQB1 antigen | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | HLA DRB1 antigen | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | adult | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | article | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | autoimmune disease | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | autoimmune polygrandular syndrome type 3 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | autoimmune thyroiditis | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | clinical feature | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | controlled study | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | CTLA4 gene | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | disease association | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | female | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | gene | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | gene frequency | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | genetic analysis | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | genetic association | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | haplotype | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | human | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | insulin dependent diabetes mellitus | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Japanese | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | major clinical study | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | male | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | onset age | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | priority journal | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | sex difference | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | single nucleotide polymorphism | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Adolescent | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Age of Onset | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Asian Continental Ancestry Group | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Autoantibodies | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Child | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Child, Preschool | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Diabetes Mellitus, Type 1 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Female | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Haplotypes | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | HLA-DQ beta-Chains | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | HLA-DRB1 Chains | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Humans | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Islets of Langerhans | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Japan | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Middle Aged | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Polyendocrinopathies | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Autoimmune | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Prevalence | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Seroepidemiologic Studies | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Sex Distribution | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Thyroiditis | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Autoimmune | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Young Adult | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Horie, Ichiro
× Horie, Ichiro× Kawasaki, Eiji× Ando, Takao× Kuwahara, Hironaga× Abiru, Norio× Usa, Toshiro× Yamasaki, Hironori× Ejima, Eri× Kawakami, Atsushi |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Objective: Type 1 diabetes (T1D) iscommonlyassociated withautoimmunethyroid disease (AITD),and the occurrence of both T1D and AITD in a patient is defined as autoimmune polyglandular syndrome type 3 variant (APS3v). We aimed to clarify the differences in the clinical and genetic characteristics of APS3v patients and T1D patients without AITD [T1D/AITD(-)] in the Japanese population. Design/Patients: Our subjects were 54 APS3v patients and 143 T1D/AITD(-) patients who were consecutively diagnosed at Nagasaki University Hospital from 1983 to the present. Results: A remarkable female predominance, a slow and older age onset of T1D, and a higher prevalence of glutamic acid decarboxylase autoantibodies were observed in APS3v patients compared to T1D/AITD(-) patients. The older onset age of T1D in APS3v patients was associated with a higher proportion of slow-onset T1D. Among the two major susceptible human leukocyte antigen (HLA) class II haplotypes in Japanese T1D, DRB1*0405- DQB1*0401, but not DRB1*0901-DQB1*0303, was associated with APS3v patients. Furthermore, DRB1*0803-DQB1*0601 was not protective in patients with APS3v. The frequencies of the GG genotype in +49G>A and +6230G>A polymorphism in the CTLA4 gene were significantly higher in T1D/AITD(-) patients, but not in APS3v patients, compared to control subjects. Conclusions: In conclusion, we found notable differences in the clinical and genetic characteristics of APS3v patients and T1D/AITD(-) patients in the Japanese population, and the differences in the clinical characteristics between the two groups may reflect distinct genetic backgrounds including the HLA DRB1-DQB1 haplotypes and CTLA4 gene polymorphisms. | |||||
書誌情報 |
Journal of Clinical Endocrinology & Metabolism 巻 97, 号 6, p. E1043-E1050, 発行日 2012-06 |
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出版者 | ||||||
出版者 | The Endocrine Society | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 0021972X | |||||
DOI | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1210/jc.2011-3109 | |||||
権利 | ||||||
権利情報 | © 2012 by The Endocrine Society. | |||||
著者版フラグ | ||||||
出版タイプ | AM | |||||
出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Journal of Clinical Endocrinology & Metabolism, 97(6), pp.E1043-E1050; 2012 |