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A thiol-mediated active membrane transport of selenium by erythroid anion exchanger 1 protein
http://hdl.handle.net/10069/29380
http://hdl.handle.net/10069/29380e4dd14e3-2201-453a-bed3-cb9936ec7238
名前 / ファイル | ライセンス | アクション |
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DalTra41_7340.pdf (3.7 MB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2013-06-29 | |||||
タイトル | ||||||
タイトル | A thiol-mediated active membrane transport of selenium by erythroid anion exchanger 1 protein | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Active membranes | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Anion exchangers | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Anion-exchange mechanism | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Buffer solutions | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Carbon dioxide transport | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Cytoplasmic domains | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Energy dependent | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Membrane spanning domains | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Membrane transport | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Red cells | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Amino acids | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Carbon dioxide | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Cell membranes | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Cytology | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Ion exchange resins | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Membranes | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Nitric oxide | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Plasmas | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Proteins | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Trace elements | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Selenium | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Hongoh, Masafumi
× Hongoh, Masafumi× Haratake, Mamoru× Fuchigami, Takeshi× Nakayama, Morio |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | In this paper, we describe a thiol-mediated and energy-dependent membrane transport of selenium by erythroid anion exchanger 1 (AE1, also known as band 3 protein). The AE1 is the most abundant integral protein of red cell membranes and plays a critical role in the carbon dioxide transport system in which carbon dioxide is carried as bicarbonate in the plasma. This protein mediates the membrane transport of selenium, an essential antioxidant micronutrient, from red cells to the plasma in a manner that is distinct from the already known anion exchange mechanism. In this pathway, selenium bound to the cysteine 93 of the hemoglobin β chain (Hb-Cysβ93) is transported by the relay mechanism to the Cys317 of the amino-terminal cytoplasmic domain of the AE1 on the basis of the intrinsic interaction between the two proteins and is subsequently exported to the plasma via the Cys843 of the membrane-spanning domain. The selenium export did not occur in plain isotonic buffer solutions and required thiols, such as albumin, in the outer medium. Such a membrane transport mechanism would also participate in the export pathways of the nitric oxide vasodilator activity and other thiol-reactive substances bound to the Hb-Cysβ93 from red cells to the plasma and/or peripherals. | |||||
書誌情報 |
Dalton Transactions 巻 41, 号 24, p. 7340-7349, 発行日 2012-06-28 |
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出版者 | ||||||
出版者 | Royal Society of Chemistry | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 14779226 | |||||
EISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 14779234 | |||||
DOI | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1039/c2dt30707c | |||||
権利 | ||||||
権利情報 | © 2012 The Royal Society of Chemistry. | |||||
著者版フラグ | ||||||
出版タイプ | AM | |||||
出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Dalton Transactions, 41(24), pp.7340-7349; 2012 |