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Protective Effects of Corni Fructus against Advanced Glycation Endproducts and Radical Scavenging
http://hdl.handle.net/10069/29406
http://hdl.handle.net/10069/2940670da9817-e8c4-4d41-ae49-ac78c765d2fe
名前 / ファイル | ライセンス | アクション |
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ECAM2012_418953.pdf (629.0 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2012-10-09 | |||||
タイトル | ||||||
タイトル | Protective Effects of Corni Fructus against Advanced Glycation Endproducts and Radical Scavenging | |||||
言語 | ||||||
言語 | jpn | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | 1 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | 1 diphenyl 2 picrylhydrazyl | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | 7 o galloyl dextro sedoheptulose | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | advanced glycation end product | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | aminoguanidine | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Corni fructus extract | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Cornus officinalis extract | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | cornuside | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | ellagitannin | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | glycoside | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | iridoid | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | loganin | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | morroniside | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | para coumaric acid | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | plant extract | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | polyphenol | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | proanthocyanidin derivative | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | quercetin glucuronide | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | scavenger | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | trolox C | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | unclassified drug | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | article | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | concentration response | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | controlled study | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | drug isolation | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | drug structure | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | fluorescence | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | in vitro study | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | priority journal | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | solvent extraction | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Park, Chan Hum
× Park, Chan Hum× Tanaka, Takashi× Kim, Hyun Young× Park, Jong Cheol× Yokozawa, Takako |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | We investigated the inhibition of advanced glycation endproduct (AGE) activity using the fluorescence characteristics of fractions and compounds from Corni Fructus. Corni Fructus extract and its iridoid glycoside components showed low inhibitory activities as well as the AGE inhibitor aminoguanidine. However, a low molecular weight polyphenol, 7-O-galloyl-D-sedoheptulose, and an antioxidant, trolox, showed high inhibitory activities compared with aminoguanidine under reactive conditions. The AGE-inhibiting activity of polyphenolic fractions of Corni Fructus ranged from a level comparable to Corni Fructus extract to the higher level of 7-O-galloyl-D-sedoheptulose. As well as the results of AGE-inhibiting activity, Corni Fructus extract and iridoid components showed low or no 1,1-diphenyl-2-pycrylhydrazyl (DPPH) radical-scavenging activities, whereas 7-O-galloyl-D-sedoheptulose showed a level comparable to trolox. Polyphenolic fractions of Corni Fructus quenched DPPH radicals in a concentration-dependent manner. Some fractions exerted a higher DPPH radical-scavenging activity compared with trolox and 7-O-galloyl-D-sedoheptulose. The DPPH radical-scavenging activity was significantly correlated with the AGE-inhibiting activity. These results suggest that polyphenolic fractions of Corni Fructus inhibited AGE formation by antioxidant activity including free radical scavenging. The strong DPPH radical-scavenging and AGE-inhibiting fractions included ellagitannins and polymeric proanthocyanidins. | |||||
書誌情報 |
Evidence-Based Complementary and Alternative Medicine 巻 2012, p. 418953, 発行日 2012 |
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出版者 | ||||||
出版者 | Hindawi Publishing Corporation | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 1741427X | |||||
EISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 17414288 | |||||
DOI | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1155/2012/418953 | |||||
権利 | ||||||
権利情報 | Copyright © 2012 Chan Hum Park et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Evidence-Based Complementary and Alternative Medicine, 2012, 418953; 2012 |