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Direct protective effects of dexmedetomidine against myocardial ischemia-reperfusion injury in anesthetized pigs
http://hdl.handle.net/10069/29498
http://hdl.handle.net/10069/294985dec708c-f085-4b47-bb0d-a3d4ef1758e8
名前 / ファイル | ライセンス | アクション |
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Shock38_92.pdf (165.4 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2013-08-01 | |||||
タイトル | ||||||
タイトル | Direct protective effects of dexmedetomidine against myocardial ischemia-reperfusion injury in anesthetized pigs | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | dexmedetomidine | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | myocardial stunning | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | norepinephrine | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | α2-adrenergic agonist | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | myocardial ischemia | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Yoshitomi, Osamu
× Yoshitomi, Osamu× Cho, Sungsam× Hara, Tetsuya× Shibata, Itsuko× Maekawa, Takuji× Ureshino, Hiroyuki× Sumikawa, Koji |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Systemic administration of α2-adrenergic agonists has been shown to protect ischemic myocardium, but the direct effects on ischemia-reperfused myocardium have not yet been clarified. This study was carried out to determine the effects of intracoronary dexmedetomidine (DEX) on the myocardial ischemia-reperfusion injury in anesthetized pigs. In open-chest pigs, the left anterior descending coronary artery was perfused through an extracorporeal circuit from the carotid artery. They received intracoronary infusion of DEX at a rate of 1 ng • mL -1 (group LD, n = 9), 10 ng • mL -1 (group MD, n = 9), or 100 ng • mL -1 (group HD, n = 9) of coronary blood flow or vehicle (group C, n = 12) for 30 min before ischemia. Myocardial stunning was produced by 12-min ischemia of the perfused area of left anterior descending coronary artery and 90-min reperfusion. The effect on reperfusion-induced arrhythmias was evaluated using the incidence of ventricular tachycardia or fibrillation after reperfusion. Regional myocardial contractility was evaluated with segment shortening (%SS). Dexmedetomidine significantly reduced the incidence of reperfusion-induced ventricular arrhythmias. Dexmedetomidine significantly improved the recovery of percentage segment shortening at 90 min after reperfusion (32.6% ± 3.1% in group C, 58.2% ± 2.1% in group LD, 61.1% ± 1.8% in group MD, and 72.0% ± 2.0% in group HD). Dexmedetomidine suppressed the increase in plasma norepinephrine concentration after reperfusion. The results indicate that DEX would exert the protective effect against ischemia-reperfusion injury by the direct action on the myocardium, which is not mediated through the central nervous system. | |||||
書誌情報 |
Shock 巻 38, 号 1, p. 92-97, 発行日 2012-07 |
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出版者 | ||||||
出版者 | Lippincott Williams and Wilkins | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 10732322 | |||||
DOI | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1097/SHK.0b013e318254d3fb | |||||
権利 | ||||||
権利情報 | © 2012 by the Shock Society. | |||||
権利 | ||||||
権利情報 | This is a non-final version of an article published in final form in Shock, 38(1), pp.92-97; 2012". | |||||
著者版フラグ | ||||||
出版タイプ | AM | |||||
出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Shock, 38(1), pp.92-97; 2012 |