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Acceleration of astrocytic differentiation in neural stem cells surviving X-irradiation
http://hdl.handle.net/10069/29510
http://hdl.handle.net/10069/295107abbe474-d361-4128-8d22-636f83b563a8
名前 / ファイル | ライセンス | アクション |
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NeuRep23_290.pdf (266.7 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2013-03-29 | |||||
タイトル | ||||||
タイトル | Acceleration of astrocytic differentiation in neural stem cells surviving X-irradiation | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Bystander signal | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Glial fibrillary acidic protein | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Nuclear factor-jB | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | X-ray | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Ozeki, Ayumi
× Ozeki, Ayumi× Suzuki, Keiji× Suzuki, Masatoshi× Ozawa, Hiroki× Yamashita, Shunichi |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Neural stem cells (NSCs) are highly susceptible to DNA double-strand breaks; however, little is known about the effects of radiation in cells surviving radiation. Although the nestin-positive NSCs predominantly became glial fibrillary acidic protein (GFAP)-positive in differentiation-permissive medium, little or no cells were GFAP positive in proliferation-permissive medium. We found that more than half of the cells surviving X-rays became GFAP positive in proliferation-permissive medium. Moreover, localized irradiation stimulated differentiation of cells outside the irradiated area. These results indicate for the first time that ionizing radiation is able to stimulate astrocyte-specific differentiation of surviving NSCs, whose process is mediated both by the direct activation of nuclear factor-jB and by the indirect bystander effect induced by X-irradiation. | |||||
書誌情報 |
NeuroReport 巻 23, 号 5, p. 290-293, 発行日 2012-03-28 |
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出版者 | ||||||
出版者 | Lippincott Williams and Wilkins | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 09594965 | |||||
DOI | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1097/WNR.0b013e3283509a79 | |||||
権利 | ||||||
権利情報 | © 2012 Wolters Kluwer Health | Lippincott Williams & Wilkins. | |||||
権利 | ||||||
権利情報 | This is a non-final version of an article published in final form in NeuroReport, 23(5), pp.290-293; 2012. | |||||
著者版フラグ | ||||||
出版タイプ | AM | |||||
出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
関係URI | ||||||
関連名称 | http://hdl.handle.net/10069/28800 | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | NeuroReport, 23(5), pp.290-293; 2012 |