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Epigallocatechin gallate suppresses peritoneal fibrosis in mice.
http://hdl.handle.net/10069/27252
http://hdl.handle.net/10069/272521e9aeb55-7421-41c3-9639-b0b95550ac72
名前 / ファイル | ライセンス | アクション |
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CBI195_95.pdf (349.3 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2012-01-20 | |||||
タイトル | ||||||
タイトル | Epigallocatechin gallate suppresses peritoneal fibrosis in mice. | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | (-)-Epigallocatechin gallate (EGCG) | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Angiogenesis | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Inflammation | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Methylglyoxal (MGO) | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Peritoneal dialysis (PD) | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Peritoneal fibrosis | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Kitamura, Mineaki
× Kitamura, Mineaki× Nishino, Tomoya× Obata, Yoko× Furusu, Akira× Hishikawa, Yoshitaka× Koji, Takehiko× Kohno, Shigeru |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Long-term peritoneal dialysis (PD) leads to histological changes in the peritoneal membrane. Angiogenesis and inflammation caused by glucose degradation products (GDPs) play crucial roles in peritoneal fibrosis. One such GDP is methylglyoxal (MGO), which enhances the formation of advanced glycation end products (AGEs). AGEs bind to their receptor (RAGE) and activate nuclear factor-κB (NF-κB), which is a key regulator of angiogenesis and inflammation. Recent studies have indicated that (-)-epigallocatechin gallate (EGCG), a tea polyphenol, inhibits angiogenesis and inflammation. Here, we examined whether EGCG suppresses peritoneal fibrosis in mice. Based on preliminary examination, 2mL of 40mM MGO or PD fluid was injected intraperitoneally and EGCG (50mg/kg) or saline was injected subcutaneously for 3weeks. In comparison to PD fluid+saline-treated mice, the peritoneal tissues of MGO+saline-treated mice showed marked thickening of the submesothelial compact zone. In the submesothelial compact zone of the MGO+saline-treated mice, CD31-positive vessels and vascular endothelial growth factor-positive cells were significantly increased, as were inflammation, F4/80-positive macrophages, and monocyte chemotactic protein-1. Moreover, 8-hydroxydeoxyguanosine, a marker of reactive oxygen species, and NF-κB, determined by Southwestern histochemistry, in the submesothelial compact zone were also increased in MGO+saline-treated mice. These changes were attenuated in MGO+EGCG-treated mice. We demonstrated that EGCG treatment suppresses peritoneal fibrosis via inhibition of NF-κB. Furthermore, EGCG inhibits reactive oxygen species production. The results of this study indicate that EGCG is a potentially novel candidate for the treatment of peritoneal fibrosis. | |||||
書誌情報 |
Chemico-Biological Interactions 巻 195, 号 1, p. 95-104, 発行日 2012-01-05 |
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出版者 | ||||||
出版者 | Elsevier Ireland Ltd. | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 00092797 | |||||
EISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 18727786 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA0060252X | |||||
PubMed番号 | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | PMID | |||||
関連識別子 | 22101032 | |||||
DOI | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1016/j.cbi.2011.11.002 | |||||
権利 | ||||||
権利情報 | Copyright © 2011 Elsevier Ireland Ltd. All rights reserved. | |||||
著者版フラグ | ||||||
出版タイプ | AM | |||||
出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
関係URI | ||||||
関連名称 | http://hdl.handle.net/10069/32641 | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Chemico-Biological Interactions, 195(1), pp.95-104; 2012 |