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Quest for a Long Life: Paradoxes and Essentials of Evolving Longevity
http://hdl.handle.net/10069/27500
http://hdl.handle.net/10069/27500f403b274-de2b-406a-80d5-cb6647976c7e
名前 / ファイル | ライセンス | アクション |
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ActMed56_73.pdf (274.6 kB)
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Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
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公開日 | 2012-02-09 | |||||
タイトル | ||||||
タイトル | Quest for a Long Life: Paradoxes and Essentials of Evolving Longevity | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | aging | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | brain | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | evolution | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | life history | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | lifespan | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | quality of life | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | departmental bulletin paper | |||||
著者 |
Mori, Nozomu
× Mori, Nozomu× Mori, Mari |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Among the countries in the developed world, Japan has the longest mean lifespan for women; however, the nation has encountered serious problems in policy and economics, as well as in managing medical care for its aging population. Aging is inevitable, but it also constitutes a major challenge in modern biology and medicine. In the treatment of geriatric patients, an understanding of the fundamental biological mechanisms of aging and longevity is crucial for the effective treatment and prevention of diseases and disorders, including dementia, osteoporosis, and sarcopenia. To address the most basic questions about aging, including determinants of lifespan and the identity of critical genes and anti-aging factors, we discuss paradoxical phenomena in the biology of longevity, with a particular focus on "time" and "size" of organisms. We also discuss essential factors and/or activities associated with anti-aging mechanisms in connection with brain function in adults and the elderly. Finally, we discuss unique features of the Shc gene family, which is involved in longevity determination, brain size restriction, cognitive functions, and evolution. The aim of this paper is to offer some insight into various problems in gerontology and geriatrics for future research. | |||||
書誌情報 |
Acta Medica Nagasakiensia 巻 56, 号 3, p. 73-80, 発行日 2012-01 |
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ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 00016055 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA00508430 | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
出版者 | ||||||
出版者 | Nagasaki University School of Medicine | |||||
出版者別言語 | ||||||
長崎大学医学部 | ||||||
sortkey | ||||||
3 | ||||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Acta Medica Nagasakiensia, 56(3), pp.73-80; 2012 |