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Effect of pH and Additives on the Compatibility between Vancomycin and Furosemide Injections
http://hdl.handle.net/10069/38373
http://hdl.handle.net/10069/38373e8831531-a7cd-4ca9-a274-60601321e73a
名前 / ファイル | ライセンス | アクション |
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Yakugaku138_853.pdf (434.1 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2018-07-12 | |||||
タイトル | ||||||
タイトル | Effect of pH and Additives on the Compatibility between Vancomycin and Furosemide Injections | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | compatibility | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | furosemide | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | generic drug | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | vancomycin | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Munakata, Chie
× Munakata, Chie× Fuchigami, Yuki× Makizoe, Takayuki× Miura, Yusuke× Yamaoka, Mariko× Sasahara, Satomi× Hata, Katsutomo× Tachiki, Hidehisa× Sasaki, Hitoshi× Hagimori, Masayori× Kawakami, Shigeru |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | The physicochemical compatibility between injections of different agents is very important. An injection of the antibiotic vancomycin (VCM) is acidic and its standard pH range is 2.5-4.5. In clinical treatments, VCM injections are often used with LasixR (furosemide) injections. The LasixR injection is alkaline and its standard pH range is 8.6-9.6. Therefore, mixing VCM injections with LasixR injections may cause compatibility problems. We evaluated the effect of pH on the compatibility between VCM (original and two generic) and LasixR injections. Compatibility was not observed in non-pH-adjusted VCM with LasixR injections, but white crystals appeared when VCM injections adjusted to pH 2.5 experimentally were mixed with a LasixR injection, suggesting that the acidic condition of VCM injections cause compatibility. However, the residual rates of VCM did not change after 24 h in all mixtures. We analyzed the crystals by mass spectrometry and 1H-NMR, and identified them to comprise furosemide. | |||||
書誌情報 |
YAKUGAKU ZASSHI en : 薬学雑誌 巻 138, 号 6, p. 853-860, 発行日 2018-06-01 |
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出版者 | ||||||
出版者 | The Pharmaceutical Society of Japan | |||||
出版者別言語 | ||||||
日本薬学会 | ||||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 00316903 | |||||
EISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 13475231 | |||||
DOI | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1248/yakushi.18-00004 | |||||
権利 | ||||||
権利情報 | c 2018 The Pharmaceutical Society of Japan. | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Yakugaku Zasshi, 138(6), pp.853-860; 2018 |