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Expression of keratinocyte growth factor (KGF) and its receptor in a middle-ear cavity problem
http://hdl.handle.net/10069/27996
http://hdl.handle.net/10069/27996090856ac-71ac-465f-97f2-4496e3580b3e
名前 / ファイル | ライセンス | アクション |
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IJPO76_76.pdf (1.9 MB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2012-03-06 | |||||
タイトル | ||||||
タイトル | Expression of keratinocyte growth factor (KGF) and its receptor in a middle-ear cavity problem | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | B cell | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Cavity problem | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Immunohistochemistry | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Keratinocyte growth factor (KGF) | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | KGF receptor (KGFR) | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Ki-67 | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Yamamoto-Fukuda, Tomomi
× Yamamoto-Fukuda, Tomomi× Takahashi, Haruo× Koji, Takehiko |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Objectives: To investigate the pathogenesis of one of the most troublesome conditions following ear surgery, a middle-ear cavity problem. Methods: Keratinocyte growth factor (KGF) and its receptor (KGFR), the ratio of proliferating epithelial cells using Ki-67, and the extent of infiltration of B cells and T cells were examined immunohistochemically in 10 ears with a cavity problem, 70 ears with cholesteatoma and 8 ears with normal skin at the retroauricular incision. Results: KGF was positive in 40% of cavity problem specimens, 37.5% of normal skin specimens, and was positive in 88% of cholesteatoma specimens (cavity problem vs. cholesteatoma, p = 0.0004). The positive rate of KGFR in the cavity problem group (33.3%) was between those in cholesteatoma (60%) and normal skin (0%). In contrast to the cholesteatoma specimens, a significantly smaller number of Ki-67 labeling index (LI) was detected in the cavity problem specimens. B cell LI was significantly higher but T cell LI was significantly lower in the cavity problem specimens than in the cholesteatoma group. Conclusions: Our present study indicated that the discordance of paracrine action between stromal KGF and epithelial KGFR with a large number of infiltrating B cells may play an important role in the pathogenesis of a cavity problem. | |||||
書誌情報 |
International Journal of Pediatric Otorhinolaryngology 巻 76, 号 1, p. 76-81, 発行日 2012-01 |
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出版者 | ||||||
出版者 | Elsevier BV | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 01655876 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA00234233 | |||||
DOI | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1016/j.ijporl.2011.10.003 | |||||
権利 | ||||||
権利情報 | Copyright © 2011 Elsevier Ireland Ltd. All rights reserved. | |||||
著者版フラグ | ||||||
出版タイプ | AM | |||||
出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | International Journal of Pediatric Otorhinolaryngology, 76(1), pp.76-81; 2012 |