WEKO3
アイテム
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Inhibitory effect of sulphated polysaccharide porphyran (isolated from Porphyra yezoensis) on RANKL-induced differentiation of RAW264.7 cells into osteoclasts
http://hdl.handle.net/10069/38415
http://hdl.handle.net/10069/384158d48086b-e403-45af-816f-2b7077affc0f
名前 / ファイル | ライセンス | アクション |
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PhyRes32_452.pdf (381.5 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2019-04-01 | |||||
タイトル | ||||||
タイトル | Inhibitory effect of sulphated polysaccharide porphyran (isolated from Porphyra yezoensis) on RANKL-induced differentiation of RAW264.7 cells into osteoclasts | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | osteoclast | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Porphyra yezoensis | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | porphyran | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | RANKL | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | RAW264.7 cells | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Ueno, Mikinori
× Ueno, Mikinori× Cho, Kichul× Isaka, Shogo× Nishiguchi, Tomoki× Yamaguchi, Kenichi× Kim, Daekyung× Oda, Tatsuya |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Safe and efficient therapeutic agents for bone diseases are required in natural sources. We previously found that edible seaweed-derived polysaccharide porphyran exhibited anti-inflammatory effects through the down regulation of nuclear factor-κB. The aim of this study was to investigate the availability of porphyran as a therapeutic agent for bone diseases. The effects of porphyran on receptor activator of nuclear factor κB ligand (RANKL)-induced osteoclastogenesis in RAW264.7 cells were examined. Porphyran suppressed RANKL-induced osteoclast formation in a concentration-dependent manner (6.25?50 μg/ml) without any cytotoxic effects. Furthermore, real-time polymerase chain reaction analyses indicated that porphyran at 50 μg/ml significantly attenuated the RANKL-induced increase in the mRNA levels of osteoclastogenesis-related marker genes such as nuclear factor of activated T cells, tartrate-resistant acid phosphatase, cathepsin K, and matrix metalloproteinase-9 in RAW264.7 cells. To our knowledge, this is the first report showing that edible-seaweed-derived polysaccharide porphyran can suppress RANKL-induced osteoclastogenesis. Our results suggest that porphyran can be used as a safe therapeutic agent to improve osteoclast-related pathological conditions. | |||||
書誌情報 |
Phytotherapy Research 巻 32, 号 3, p. 452-458, 発行日 2018-03 |
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出版者 | ||||||
出版者 | John Wiley and Sons Ltd | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 0951418X | |||||
DOI | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1002/ptr.5988 | |||||
権利 | ||||||
権利情報 | c 2017 John Wiley & Sons, Ltd. This is the peer reviewed version of the following article: Phytotherapy Research, 32(3), pp.452-458; 2018, which has been published in final form at http://dx.doi.org/10.1002/ptr.5988. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving. | |||||
著者版フラグ | ||||||
出版タイプ | AM | |||||
出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Phytotherapy Research, 32(3), pp.452-458; 2018 |