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Mitochondrial dysfunction, a probable cause of persistent oxidative stress after exposure to ionizing radiation
http://hdl.handle.net/10069/28135
http://hdl.handle.net/10069/28135b40c771b-deec-4ca7-b100-a695db865b41
名前 / ファイル | ライセンス | アクション |
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FRR46_147.pdf (296.4 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2013-03-01 | |||||
タイトル | ||||||
タイトル | Mitochondrial dysfunction, a probable cause of persistent oxidative stress after exposure to ionizing radiation | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | 8-hydroxy-2′-deoxyguanosine | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | mitochondrial dysfunction | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | oxidative stress | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | radiation | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | reactive oxygen species | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Yoshida, Takako
× Yoshida, Takako× Goto, Shinji× Kawakatsu, Miho× Urata, Yoshishige× Li, Tao-sheng |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Several recent studies have suggested that the reactive oxygen species (ROS) generated from mitochondria contribute to genomic instability after exposure of the cells to ionizing radiation, but the mechanism of this process is not yet fully understood. We examined the hypothesis that irradiation induces mitochondrial dysfunction to cause persistent oxidative stress, which contributes to genomic instability. After the exposure of cells to 5 Gy gamma-ray irradiation, we found that the irradiation induced the following changes in a clear pattern of time courses. First, a robust increase of intracellular ROS levels occurred within minutes, but the intracellular ROS disappeared within 30 min. Then the mitochondrial dysfunction was detected at 12 h after irradiation, as indicated by the decreased activity of NADH dehydrogenase (Complex I), the most important enzyme in regulating the release of ROS from the mitochondrial electron transport chain (ETC). Finally, a significant increase of ROS levels in the mitochondria and the oxidation of mitochondrial DNA were observed in cells at 24 h or later after irradiation. Although further experiments are required, results in this study support the hypothesis that mitochondrial dysfunction causes persistent oxidative stress that may contribute to promote radiation-induced genomic instability. | |||||
書誌情報 |
Free Radical Research 巻 46, 号 2, p. 147-153, 発行日 2012-02 |
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出版者 | ||||||
出版者 | Informa Healthcare | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 10715762 | |||||
EISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 10292470 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA11001805 | |||||
DOI | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.3109/10715762.2011.645207 | |||||
権利 | ||||||
権利情報 | © 2012 Informa UK, Ltd. | |||||
著者版フラグ | ||||||
出版タイプ | AM | |||||
出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Free Radical Research, 46(2), pp.147-153; 2012 |