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Clinical efficacy and safety of micafungin in Japanese patients with chronic pulmonary aspergillosis: a prospective observational study.
http://hdl.handle.net/10069/27429
http://hdl.handle.net/10069/274299a95f6f4-4305-4710-80c0-d09a9a606395
名前 / ファイル | ライセンス | アクション |
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MedMyc49_688.pdf (161.8 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2012-11-01 | |||||
タイトル | ||||||
タイトル | Clinical efficacy and safety of micafungin in Japanese patients with chronic pulmonary aspergillosis: a prospective observational study. | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Chronic pulmonary aspergillosis | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | efficacy | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | micafungin | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | observational study | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | safety | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Kohno, Shigeru
× Kohno, Shigeru× Izumikawa, Koichi× Kakeya, Hiroshi× Miyazaki, Yoshitsugu× Ogawa, Kenji× Amitani, Ryoichi× Niki, Yoshihito× Kurashima, Atsuyuki |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Aspergillosis has been the prevailing deep-seated mycosis in Japan since the 1990s. Although micafungin (MCFG) has been approved in Japan for the management of patients with such infections caused by Candida and Aspergillus species, there are relatively few reports on its use in patients with chronic pulmonary aspergillosis (CPA). Therefore, we conducted a prospective observational study to evaluate the efficacy and safety of the use of MCFG in Japanese patients with CPA. The efficacy of the antifungal was assessed on the basis of improvements in clinical symptoms and radiological findings. In addition, adverse events, including abnormal laboratory findings were determined. The overall clinical efficacy rate was 68.4% (26/38 patients), which is comparable to the results obtained in clinical trials for marketing approval conducted in Japan. Although adverse drug reactions were observed in six patients (15.8%), they were not serious. The most common of these reactions was abnormal liver functions. No relationship between the incidence of adverse drug reactions and age of the patients, MCFG dose, or duration of treatment was observed. Consequently, MCFG has favorable efficacy and safety profiles in Japanese CPA patients with various backgrounds. | |||||
書誌情報 |
Medical Mycology : official publication of the International Society for Human and Animal Mycology 巻 49, 号 7, p. 688-693, 発行日 2011-10 |
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出版者 | ||||||
出版者 | Informa Healthcare | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 13693786 | |||||
EISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 14602709 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA11233800 | |||||
PubMed番号 | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | PMID | |||||
関連識別子 | 21355713 | |||||
DOI | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.3109/13693786.2011.561369 | |||||
権利 | ||||||
権利情報 | © 2011 ISHAM. | |||||
権利 | ||||||
権利情報 | This is an electronic version of an article published in Medical Mycology, 49(7), pp.688-693; 2011. Medical Mycology is available online at: http://dx.doi.org/10.3109/13693786.2011.561369 | |||||
著者版フラグ | ||||||
出版タイプ | AM | |||||
出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Medical Mycology, 49(7), pp.688-693; 2011 |