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Development of Effective Cancer Vaccine Using Targeting System of Antigen Protein to APCs.
http://hdl.handle.net/10069/26167
http://hdl.handle.net/10069/2616798244e64-3ff7-4aa4-bb49-037df3a7ffdb
名前 / ファイル | ライセンス | アクション |
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PhaRes_Kurosaki.pdf (234.6 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2011-10-31 | |||||
タイトル | ||||||
タイトル | Development of Effective Cancer Vaccine Using Targeting System of Antigen Protein to APCs. | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | γ-polyglutamic acid | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | benzalkonium chloride | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | cancer | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | delivery system | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | vaccine | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Kurosaki, Tomoaki
× Kurosaki, Tomoaki× Kitahara, Takashi× Nakamura, Tadahiro× Nishida, Koyo× Fumoto, Shintaro× Kodama, Yukinobu× Nakagawa, Hiroo× Higuchi, Norihide× Sasaki, Hitoshi |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | PURPOSE: To develop a novel cancer vaccine using the targeting system of antigen protein to antigen-presenting cells (APCs) for efficient and safe cancer therapy. METHODS: The novel delivery system was constructed with antigen protein, benzalkonium chloride (BK), and γ-polyglutamic acid (γ-PGA), using ovalbumin (OVA) as a model antigen protein and evaluating its immune induction effects and utilities for cancer vaccine. RESULTS: BK and γ-PGA enabled encapsulation of OVA and formed stable anionic particles at nanoscale, OVA/BK/γ-PGA complex. Complex was taken up by dendritic cell line DC2.4 cells efficiently. We subcutaneously administered the complex to mice and examined induction of IgGs. The complex induced not only Th2-type immunoglobulins but also Th1-type immunoglobulins. OVA/BK/γ-PGA complex inhibited tumor growth of E.G7 cells expressing OVA regularly; administered OVA/BK/γ-PGA complex completely rejected tumor cells. CONCLUSION: The novel vaccine could be platform technology for a cancer vaccine. | |||||
書誌情報 |
Pharmaceutical Research 巻 -, 号 -, p. ---, 発行日 2011-09-02 |
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出版者 | ||||||
出版者 | Springer | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 07248741 | |||||
EISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 1573904X | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA10632083 | |||||
PubMed番号 | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | PMID | |||||
関連識別子 | 21887598 | |||||
DOI | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1007/s11095-011-0571-x | |||||
権利 | ||||||
権利情報 | © Springer Science+Business Media, LLC 2011 | |||||
権利 | ||||||
権利情報 | The original publication is available at www.springerlink.com | |||||
著者版フラグ | ||||||
出版タイプ | AM | |||||
出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Pharmaceutical Research, Article in Press |