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Por Secretion System of Porphyromonas gingivalis
http://hdl.handle.net/10069/26191
http://hdl.handle.net/10069/26191c643d44c-fa76-436f-87d2-cb870e5234ab
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
JOB53_187.pdf (1.3 MB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||
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| 公開日 | 2011-11-01 | |||||
| タイトル | ||||||
| タイトル | Por Secretion System of Porphyromonas gingivalis | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Bacteroidetes phylum | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Periodontal pathogen | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Proteinase | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| 著者 |
Sato, Keiko
× Sato, Keiko |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | The virulence factors of pathogenic bacteria are major secretory proteins that are directly linked to their pathogenicity These secretory proteins are translocated across the membranes of bacterial cells by translocase nanomachines, which consists of integral membrane proteins. The periodontal pathogen, Porphyromonas gingivalis, secretes trypsin-like proteases (gingipains) either as a large complex on the bacterial cell surface or into the extracellular milieu. Gingipains are important virulence factors, because they degrade host proteins. They are responsible for the processing/maturation of other P. gingivalis virulence factors. At least six types of translocase nanomachines have been found in Gram-negative bacteria ; however, P. gingivalis does not have genes homologous to those coding these secretion systems in the bacterial genome and not much is known about the mechanism of gingipain secretion. In this study, the proteins responsible for gingipain secretion, i.e., PorK, PorL, PorM, PorN, and PorW, were identified by comparative genome analysis and genetic experiments. We named the gingipain secretion system the Por secretion system (PorSS). Genes encoding PorSS proteins are conserved among a group of bacteria including periodontal pathogens such as Tannellera forsythia and Prevotella intermedia in the phylum Bacteroidetes. In addition, homologous genes are involved in gliding motility and chitinase secretion in Flavobacterium johnsoniae, another member of the phylum Bacteroidetes. Two other genes, porX and porY, encoding the regulatory factors of PorSS gene expression were identified at the same time. The expression of the porT, porK, porL, porM, and porN genes was downregulated in PorX- or PorY-defective mutants. PorSS and its regulatory system appear to be associated with the pathogenicity of various bacteria in the phylum Bacteroidetes. | |||||
| 書誌情報 |
Journal of Oral Biosciences 巻 53, 号 3, p. 187-196, 発行日 2011-09-06 |
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| 出版者 | ||||||
| 出版者 | Japanese Association for Oral Biology | |||||
| 出版者別言語 | ||||||
| 値 | 歯科基礎医学会 | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 13490079 | |||||
| EISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 18803865 | |||||
| 書誌レコードID | ||||||
| 収録物識別子タイプ | NCID | |||||
| 収録物識別子 | AA11896386 | |||||
| DOI | ||||||
| 関連タイプ | isIdenticalTo | |||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.2330/joralbiosci.53.187 | |||||
| 権利 | ||||||
| 権利情報 | Copyright (c) 2011 by Japanese Association for Oral Biology | |||||
| 著者版フラグ | ||||||
| 出版タイプ | VoR | |||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
| 引用 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | Journal of Oral Biosciences, 53(3), pp.187-196; 2011 | |||||
