WEKO3
アイテム
{"_buckets": {"deposit": "1acddf90-68ea-4527-933f-32f8e819d593"}, "_deposit": {"created_by": 2, "id": "12264", "owners": [2], "pid": {"revision_id": 0, "type": "depid", "value": "12264"}, "status": "published"}, "_oai": {"id": "oai:nagasaki-u.repo.nii.ac.jp:00012264", "sets": ["9"]}, "author_link": ["45780", "45783", "45784", "45785", "45781", "45779", "45782", "45786"], "item_2_biblio_info_6": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2012-01-10", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "2", "bibliographicPageEnd": "209", "bibliographicPageStart": "205", "bibliographicVolumeNumber": "491", "bibliographic_titles": [{"bibliographic_title": "Gene"}]}]}, "item_2_description_4": {"attribute_name": "抄録", "attribute_value_mlt": [{"subitem_description": "We have developed a novel vector constructed with pDNA, polyethylenimine (PEI), and mucin 1 (MUC1) aptamer for tumor-targeted gene delivery. The MUC1 aptamer and non-specific aptamer were employed to coat the pDNA/PEI complexes electrostatically and stable nanoparticles were formed. The addition of a non-specific aptamer to the pDNA/PEI complex decreased gene expression in the human lung cancer cell line, A549 cells expressing MUC1 regularly. At the same time, the pDNA/PEI/MUC1 aptamer complex showed higher gene expression than pDNA/PEI/non-specific aptamer complex. Furthermore, the pDNA/PEI/MUC1 aptamer complex showed markedly high gene expression in tumor-bearing mice; thus, pDNA/PEI/MUC1 aptamer complexes are useful as a tumor-targeted gene delivery system with high transfection efficiency.", "subitem_description_type": "Abstract"}]}, "item_2_description_63": {"attribute_name": "引用", "attribute_value_mlt": [{"subitem_description": "Gene, 491(2), pp.205-209; 2012", "subitem_description_type": "Other"}]}, "item_2_publisher_33": {"attribute_name": "出版者", "attribute_value_mlt": [{"subitem_publisher": "Elsevier BV"}]}, "item_2_relation_11": {"attribute_name": "PubMed番号", "attribute_value_mlt": [{"subitem_relation_type": "isVersionOf", "subitem_relation_type_id": {"subitem_relation_type_id_text": "22001405", "subitem_relation_type_select": "PMID"}}]}, "item_2_relation_12": {"attribute_name": "DOI", "attribute_value_mlt": [{"subitem_relation_type": "isVersionOf", "subitem_relation_type_id": {"subitem_relation_type_id_text": "10.1016/j.gene.2011.09.021", "subitem_relation_type_select": "DOI"}}]}, "item_2_rights_13": {"attribute_name": "権利", "attribute_value_mlt": [{"subitem_rights": "Copyright © 2011 Published by Elsevier B.V."}]}, "item_2_source_id_10": {"attribute_name": "書誌レコードID", "attribute_value_mlt": [{"subitem_source_identifier": "AA00654385", "subitem_source_identifier_type": "NCID"}]}, "item_2_source_id_7": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "03781119", "subitem_source_identifier_type": "ISSN"}]}, "item_2_source_id_8": {"attribute_name": "EISSN", "attribute_value_mlt": [{"subitem_source_identifier": "18790038", "subitem_source_identifier_type": "ISSN"}]}, "item_2_version_type_16": {"attribute_name": "著者版フラグ", "attribute_value_mlt": [{"subitem_version_resource": "http://purl.org/coar/version/c_ab4af688f83e57aa", "subitem_version_type": "AM"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Kurosaki, Tomoaki"}], "nameIdentifiers": [{"nameIdentifier": "45779", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Higuchi, Norihide"}], "nameIdentifiers": [{"nameIdentifier": "45780", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Kawakami, Shigeru"}], "nameIdentifiers": [{"nameIdentifier": "45781", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Higuchi, Yuriko"}], "nameIdentifiers": [{"nameIdentifier": "45782", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Nakamura, Tadahiro"}], "nameIdentifiers": [{"nameIdentifier": "45783", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Kitahara, Takashi"}], "nameIdentifiers": [{"nameIdentifier": "45784", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Hashida, Mitsuru"}], "nameIdentifiers": [{"nameIdentifier": "45785", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Sasaki, Hitoshi"}], "nameIdentifiers": [{"nameIdentifier": "45786", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2020-12-22"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "Gene491_205.pdf", "filesize": [{"value": "181.8 kB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_free", "mimetype": "application/pdf", "size": 181800.0, "url": {"label": "Gene491_205.pdf", "url": "https://nagasaki-u.repo.nii.ac.jp/record/12264/files/Gene491_205.pdf"}, "version_id": "f1c21078-34fa-44d9-a3cf-2f0e4fb36902"}]}, "item_keyword": {"attribute_name": "キーワード", "attribute_value_mlt": [{"subitem_subject": "Aptamer", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Gene delivery", "subitem_subject_scheme": "Other"}, {"subitem_subject": "MUC1", "subitem_subject_scheme": "Other"}, {"subitem_subject": "pDNA", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Polyethylenimine", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "journal article", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "Self-assemble gene delivery system for molecular targeting using nucleic acid aptamer.", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "Self-assemble gene delivery system for molecular targeting using nucleic acid aptamer."}]}, "item_type_id": "2", "owner": "2", "path": ["9"], "permalink_uri": "http://hdl.handle.net/10069/26393", "pubdate": {"attribute_name": "公開日", "attribute_value": "2011-11-15"}, "publish_date": "2011-11-15", "publish_status": "0", "recid": "12264", "relation": {}, "relation_version_is_last": true, "title": ["Self-assemble gene delivery system for molecular targeting using nucleic acid aptamer."], "weko_shared_id": 2}
Self-assemble gene delivery system for molecular targeting using nucleic acid aptamer.
http://hdl.handle.net/10069/26393
http://hdl.handle.net/10069/26393c8c4434e-7088-46b1-9d91-808a119220c2
名前 / ファイル | ライセンス | アクション |
---|---|---|
Gene491_205.pdf (181.8 kB)
|
|
Item type | 学術雑誌論文 / Journal Article(1) | |||||
---|---|---|---|---|---|---|
公開日 | 2011-11-15 | |||||
タイトル | ||||||
タイトル | Self-assemble gene delivery system for molecular targeting using nucleic acid aptamer. | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Aptamer | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Gene delivery | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | MUC1 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | pDNA | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Polyethylenimine | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Kurosaki, Tomoaki
× Kurosaki, Tomoaki× Higuchi, Norihide× Kawakami, Shigeru× Higuchi, Yuriko× Nakamura, Tadahiro× Kitahara, Takashi× Hashida, Mitsuru× Sasaki, Hitoshi |
|||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | We have developed a novel vector constructed with pDNA, polyethylenimine (PEI), and mucin 1 (MUC1) aptamer for tumor-targeted gene delivery. The MUC1 aptamer and non-specific aptamer were employed to coat the pDNA/PEI complexes electrostatically and stable nanoparticles were formed. The addition of a non-specific aptamer to the pDNA/PEI complex decreased gene expression in the human lung cancer cell line, A549 cells expressing MUC1 regularly. At the same time, the pDNA/PEI/MUC1 aptamer complex showed higher gene expression than pDNA/PEI/non-specific aptamer complex. Furthermore, the pDNA/PEI/MUC1 aptamer complex showed markedly high gene expression in tumor-bearing mice; thus, pDNA/PEI/MUC1 aptamer complexes are useful as a tumor-targeted gene delivery system with high transfection efficiency. | |||||
書誌情報 |
Gene 巻 491, 号 2, p. 205-209, 発行日 2012-01-10 |
|||||
出版者 | ||||||
出版者 | Elsevier BV | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 03781119 | |||||
EISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 18790038 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA00654385 | |||||
PubMed番号 | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | PMID | |||||
関連識別子 | 22001405 | |||||
DOI | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1016/j.gene.2011.09.021 | |||||
権利 | ||||||
権利情報 | Copyright © 2011 Published by Elsevier B.V. | |||||
著者版フラグ | ||||||
出版タイプ | AM | |||||
出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Gene, 491(2), pp.205-209; 2012 |