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Antigenic mimicry-mediated anti-prion effects induced by bacterial enzyme succinylarginine dihydrolase in mice.
http://hdl.handle.net/10069/26410
http://hdl.handle.net/10069/264107a89c5f0-7efd-4e9f-a183-46ab19f72641
名前 / ファイル | ライセンス | アクション |
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Vaccine29_9321.pdf (889.6 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2011-11-16 | |||||
タイトル | ||||||
タイトル | Antigenic mimicry-mediated anti-prion effects induced by bacterial enzyme succinylarginine dihydrolase in mice. | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Antigenic mimicry | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Humoral immunity | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Prion | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Vaccine | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Ishibashi, Daisuke
× Ishibashi, Daisuke× Yamanaka, Hitoki× Mori, Tsuyoshi× Yamaguchi, Naohiro× Yamaguchi, Yoshitaka× Nishida, Noriyuki× Sakaguchi, Suehiro |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Prions, the causative agents of prion diseases, are immunologically tolerated because their major component, prion protein (PrP), is a host-encoded molecule. Therefore, no effective prion vaccines have been developed. We previously showed that heterologous bovine and sheep PrP immunizations of mice overcame tolerance by an antigenic mimicry mechanism to efficiently induce anti-PrP auto-antibodies (Abs), significantly prolonging incubation times in mice subsequently infected with the mouse-adapted Fukuoka-1 prion. These results prompted us to investigate if non-mammal derived molecules able to antigenically mimic anti-prion epitopes, could act as prion vaccines. We show here that immunization of mice with recombinant succinylarginine dihydrolase, a bacterial enzyme with a peptide sequence similar to an anti-prion epitope, induced anti-PrP auto-Abs with anti-prion activity and significantly retarded survival times of the mice subsequently infected with Fukuoka-1 prions. These results might open a way for development of a new type of antigenic mimicry-based prion vaccine. | |||||
書誌情報 |
Vaccine 巻 29, 号 50, p. 9321-9328, 発行日 2011-11-21 |
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出版者 | ||||||
出版者 | Elsevier BV | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 18732518 | |||||
EISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 13588745 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA10491877 | |||||
PubMed番号 | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | PMID | |||||
関連識別子 | 22008817 | |||||
DOI | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1016/j.vaccine.2011.10.017 | |||||
権利 | ||||||
権利情報 | Copyright © 2011 Elsevier Ltd. All rights reserved. | |||||
著者版フラグ | ||||||
出版タイプ | AM | |||||
出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Vaccine, 29(50), pp.9321-9328; 2011 |