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Alkyl-glycerophosphate-mediated C-C motif chemokine 2 secretion induces oxidative stress via increased PPARγ activation in human umbilical vein endothelial cells
http://hdl.handle.net/10069/38499
http://hdl.handle.net/10069/384995e98f90c-ecec-46bb-a2f7-9b387a835c0b
名前 / ファイル | ライセンス | アクション |
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BioPha106_686.pdf (3.9 MB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2019-11-01 | |||||
タイトル | ||||||
タイトル | Alkyl-glycerophosphate-mediated C-C motif chemokine 2 secretion induces oxidative stress via increased PPARγ activation in human umbilical vein endothelial cells | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | AGP | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | CCL-2 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Peroxidation | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | PPARγ | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | ROS | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Tsukahara, Tamotsu
× Tsukahara, Tamotsu× Yamagishi, Shuhei× Matsuda, Yoshikazu× Haniu, Hisao |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | We previously showed that an alkyl-ether analog of lysophosphatidic acid, AGP (alkyl-glycerophosphate), accumulates in human atherosclerotic plaques and is a potent agonist of peroxisome proliferator-activated receptor-gamma (PPARγ). On the other hand, cyclic phosphatidic acid (cPA), similar in structure to AGP, can negatively regulate PPARγ. However, in this study, cPA had no effect on the expression and secretion of C-C motif chemokine 2 (CCL-2), a chemokine that is also linked to inflammatory responses and atherosclerosis. We showed that AGP enhances CCL-2 mRNA expression and secretion in a dose-dependent manner. Furthermore, oxidative stress plays a major role in the pathology of cardiovascular diseases; we showed that AGP triggers ROS generation and lipid peroxidation and that ROS and 8-isoprostane generation can be suppressed by a PPARγ antagonist. These results suggest that an imbalance of the PPARγ agonist-antagonist equilibrium is involved in changes in cellular functions, including ROS generation and lipid peroxidation. | |||||
書誌情報 |
Biomedicine & Pharmacotherapy 巻 106, p. 686-691, 発行日 2018-09 |
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出版者 | ||||||
出版者 | Elsevier Masson SAS | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 07533322 | |||||
DOI | ||||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1016/j.biopha.2018.07.012 | |||||
権利 | ||||||
権利情報 | c 2018 Elsevier Masson SAS. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/ | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Biomedicine and Pharmacotherapy, 106, pp.686-691; 2018 |