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In vivo efficacy of KRP-109, a novel elastase inhibitor, in a murine model of severe pneumococcal pneumonia.
http://hdl.handle.net/10069/26864
http://hdl.handle.net/10069/26864f255992e-0d4a-4505-9ff9-903c73410b87
名前 / ファイル | ライセンス | アクション |
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PPT24_660.pdf (957.7 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2011-12-20 | |||||
タイトル | ||||||
タイトル | In vivo efficacy of KRP-109, a novel elastase inhibitor, in a murine model of severe pneumococcal pneumonia. | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Immunomodulation therapy | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Neutrophil elastase | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Streptococcus pneumonia | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Yamada, Koichi
× Yamada, Koichi× Yanagihara, Katsunori× Araki, Nobuko× Harada, Yosuke× Morinaga, Yoshitomo× Izumikawa, Koichi× Kakeya, Hiroshi× Yamamoto, Yoshihiro× Hasegawa, Hiroo× Kohno, Shigeru× Kamihira, Shimeru |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | KRP-109 is a novel specific inhibitor of neutrophil elastase (NE). Various studies suggest that NE inhibitors reduce lung injury associated with systemic inflammatory response syndrome (SIRS). In this study, the efficacy of KRP-109 was examined using a murine model of severe pneumonia induced by Streptococcus pneumoniae (S. pneumoniae). Female mice (CBA/J, aged 5 weeks) were inoculated intranasally with penicillin-susceptible S. pneumoniae (ATCC49619 strain, 2.5 × 10(8) CFU/mouse). KRP-109 (30 or 50 mg/kg) or physiological saline as a control was administered intraperitoneally every 8 h beginning at 8 h after inoculation, and survival rate was evaluated over 7 days. Histopathological and bacteriological analyses of the lung, and bronchoalveolar lavage were performed at 48 h post-infection. The mice treated with KRP-109 (KRP-109 mice) tended to have higher survival rate than those given saline. The lung tissues of the KRP-109 mice had few neutrophils in the alveolar walls and less inflammation. Furthermore, KRP-109 decreased significantly total cell and neutrophil counts, and cytokine levels (interleukin 1β and macrophage inflammatory protein 2) in bronchoalveolar lavage fluid. Viable bacterial numbers in lung were not influenced by treatment of KRP-109. The present results indicate that KRP-109 reduces lung inflammation in a murine model, and that KRP-109 may be useful for the treatment of patients with severe pneumonia. | |||||
書誌情報 |
Pulmonary Pharmacology & Therapeutics 巻 24, 号 6, p. 660-665, 発行日 2011-12 |
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出版者 | ||||||
出版者 | Elsevier Ltd. | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 10945539 | |||||
EISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 15229629 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA1115999X | |||||
PubMed番号 | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | PMID | |||||
関連識別子 | 21864700 | |||||
DOI | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1016/j.pupt.2011.08.001 | |||||
権利 | ||||||
権利情報 | Copyright © 2011 Elsevier Ltd. All rights reserved. | |||||
著者版フラグ | ||||||
出版タイプ | AM | |||||
出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
関係URI | ||||||
関連名称 | http://hdl.handle.net/10069/29737 | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Pulmonary Pharmacology & Therapeutics, 24(6), pp.660-665; 2011 |