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Interferon regulatory factor-4 activates IL-2 and IL-4 promoters in cooperation with c-Rel.
http://hdl.handle.net/10069/27006
http://hdl.handle.net/10069/27006a348ae14-5d8a-4861-b5cc-c0e700eaf72e
名前 / ファイル | ライセンス | アクション |
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Cytokine56_564.pdf (819.7 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2012-01-04 | |||||
タイトル | ||||||
タイトル | Interferon regulatory factor-4 activates IL-2 and IL-4 promoters in cooperation with c-Rel. | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Adult T-cell leukemia/lymphoma (ATLL) | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | C-Rel | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | IL-2 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | IL-4 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Interferon regulatory factor (IRF)-4 | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Shindo, Hisakazu
× Shindo, Hisakazu× Yasui, Kiyoshi× Yamamoto, Kazuo× Honma, Kiri× Yui, Katsuyuki× Kohno, Tomoko× Ma, Yuhua× Chua, Koon Jiew× Kubo, Yoshinao× Aihara, Hitoshi× Ito, Takashi× Nagayasu, Takeshi× Matsuyama, Toshifumi× Hayashi, Hideki |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Interferon regulatory factor (IRF)-4 is a member of the IRF transcription factor family, whose expression is primarily restricted to lymphoid and myeloid cells. In T-cells, IRF-4 expression is induced by T-cell receptor (TCR) cross-linking or treatment with phorbol-12-myristate-13-acetate (PMA)/Ionomycin, and IRF-4 is thought to be a critical factor for various functions of T-cells. To elucidate the IRF-4 functions in human adult T-cell leukemia virus type 1 (HTLV-1)-infected T-cells, which constitutively express IRF-4, we isolated IRF-4-binding proteins from T-cells, using a tandem affinity purification (TAP)-mass spectrometry strategy. Fourteen proteins were identified in the IRF-4-binding complex, including endogenous IRF-4 and the nuclear factor-kappaB (NF-κB) family member, c-Rel. The specific association of IRF-4 with c-Rel was confirmed by immunoprecipitation experiments, and IRF-4 was shown to enhance the c-Rel-dependent binding and activation of the interleukin-4 (IL-4) promoter region. We also demonstrated that IL-2 production was also enhanced by exogenously-expressed IRF-4 and c-Rel in the presence of P/I, in T-cells, and that the optimal IL-2 and IL-4 productions in vivo was IRF-4-dependent using IRF-4-/- mice. These data provide molecular evidence to support the clinical observation that elevated expression of c-Rel and IRF-4 is associated with the prognosis in adult T-cell leukemia/lymphoma (ATLL) patients, and present possible targets for future gene therapy. | |||||
書誌情報 |
Cytokine 巻 56, 号 3, p. 564-572, 発行日 2011-12 |
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出版者 | ||||||
出版者 | Elsevier Ltd. | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 10434666 | |||||
EISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 10960023 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA10794201 | |||||
PubMed番号 | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | PMID | |||||
関連識別子 | 21890374 | |||||
DOI | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1016/j.cyto.2011.08.014 | |||||
権利 | ||||||
権利情報 | Copyright © 2011 Elsevier Ltd. All rights reserved. | |||||
著者版フラグ | ||||||
出版タイプ | AM | |||||
出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Cytokine, 56(3), pp.564-572; 2011 |