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Increase of apoptosis in a murine model for severe pneumococcal pneumonia during influenza A virus infection
http://hdl.handle.net/10069/27108
http://hdl.handle.net/10069/2710861953cf0-da76-4d3a-9d3b-233aaa5066d9
名前 / ファイル | ライセンス | アクション |
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JJID64_451.pdf (563.0 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2012-01-12 | |||||
タイトル | ||||||
タイトル | Increase of apoptosis in a murine model for severe pneumococcal pneumonia during influenza A virus infection | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Kosai, Kosuke
× Kosai, Kosuke× Seki, Masafumi× Tanaka, Akitaka× Morinaga, Yoshitomo× Imamura, Yoshifumi× Izumikawa, Koichi× Kakeya, Hiroshi× Yamamoto, Yoshihiro× Yanagihara, Katsunori× Tomono, Kazunori× Kohno, Shigeru |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | The mechanisms of severe pneumonia caused by co-infection of bacteria and influenza A virus (IAV) have not been fully elucidated. We examined apoptosis and inflammatory responses in a murine model for pneumococcal pneumonia during IAV infection. Inflammation, respiratory epithelium apoptosis, and inflammatory-cell infiltration increased in a time dependent manner in the lungs of mice co-infected with Streptococcus pneumoniae and IAV, in comparison with those infected with either S. pneumoniae or IAV. According to appearance of terminal deoxynucleotidyl transferase dUTPmediated nick-end labeling positive cells, caspase-3 and -8 were activated 24 h after S. pneumoniae infection, and caspase-3 activation decreased after 48 h, whereas inflammatory cytokine levels continued to increase in co-infected mice. In contrast, in mice infected with either IAV or S. pneumoniae, apoptosis and activation of factors related to caspase-3 peaked at 48 h. Furthermore, Fas-associated death domain was significantly expressed in the lungs of co-infected mice 24 h after S. pneumoniae infection. These data suggest that early onset of apoptosis and its related factors play important roles in fulminant pneumonia resulting from bacterial pneumonia complicated by co-infection with influenza virus. | |||||
書誌情報 |
Japanese Journal of Infectious Diseases 巻 64, 号 6, p. 451-457, 発行日 2011 |
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出版者 | ||||||
出版者 | National Institute of Infectious Diseases | |||||
出版者別言語 | ||||||
国立感染症研究所 | ||||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 13446304 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA1132885X | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Japanese Journal of Infectious Diseases, 64(6), pp.451-457; 2011 |