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Differential requirements for IRF4 in the clonal expansion and homeostatic proliferation of naive and memory murine CD8+ T?cells
http://hdl.handle.net/10069/38570
http://hdl.handle.net/10069/3857086be7fb0-12b6-4253-ad8f-0171a809df5b
名前 / ファイル | ライセンス | アクション |
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EJI48_1319.pdf (3.0 MB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2019-09-01 | |||||
タイトル | ||||||
タイトル | Differential requirements for IRF4 in the clonal expansion and homeostatic proliferation of naive and memory murine CD8+ T?cells | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | CD8+Tcells | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Homeostasis | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Memory cell | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Signal transduction | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Transcription factors | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Miyakoda, Mana
× Miyakoda, Mana× Honma, Kiri× Kimura, Daisuke× Akbari, Masoud× Kimura, Kazumi× Matsuyama, Toshifumi× Yui, Katsuyuki |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Interferon regulatory factor 4 (IRF4) has critical roles in immune cell differentiation and function and is indispensable for clonal expansion and effector function in T cells. Here, we demonstrate that the AKT pathway is impaired in murine CD8+ T cells lacking IRF4. The expression of phosphatase and tensin homolog (PTEN), a negative regulator of the AKT pathway, was elevated in Irf4?/? CD8+ T cells. Inhibition of PTEN partially rescued downstream events, suggesting that PTEN constitutes a checkpoint in the IRF4-mediated regulation of cell signaling. Despite the clonal expansion defect, in the absence of IRF4, memory-like CD8+ T cells could be generated and maintained, although unable to expand in recall responses. The homeostatic proliferation of naive Irf4?/? CD8+ T cells was impaired, whereas their number eventually reached a level similar to that of wild-type CD8+ T cells. Conversely, memory-like Irf4?/? CD8+ T cells underwent homeostatic proliferation in a manner similar to that of wild-type memory CD8+ T cells. These results suggest that IRF4 regulates the clonal expansion of CD8+ T cells at least in part via the AKT signaling pathway. Moreover, IRF4 regulates the homeostatic proliferation of naive CD8+ T cells, whereas the maintenance of memory CD8+ T cells is IRF4-independent. |
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書誌情報 |
European Journal of Immunology 巻 48, 号 8, p. 1319-1328, 発行日 2018-08 |
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出版者 | ||||||
出版者 | WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 00142980 | |||||
DOI | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1002/eji.201747120 | |||||
権利 | ||||||
権利情報 | c 2018 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. This is the peer reviewed version of the following article:European Journal of Immunology, 48(8), pp.1319-1328; 2018 , which has been published in final form at 10.1002/eji.201747120. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. | |||||
著者版フラグ | ||||||
出版タイプ | AM | |||||
出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | European Journal of Immunology, 48(8), pp.1319-1328; 2018 |