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Distribution of dipeptidyl peptidase (DPP) 4, DPP5, DPP7, and DPP11 in human oral microbiota ? potent biomarkers indicating presence of periodontopathic bacteria
http://hdl.handle.net/10069/38571
http://hdl.handle.net/10069/38571f1538a4a-b83b-4f0e-b3ae-1e2e2cb7d28d
名前 / ファイル | ライセンス | アクション |
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FEMSML_fny221.pdf (955.2 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2019-09-10 | |||||
タイトル | ||||||
タイトル | Distribution of dipeptidyl peptidase (DPP) 4, DPP5, DPP7, and DPP11 in human oral microbiota ? potent biomarkers indicating presence of periodontopathic bacteria | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | dental plaque | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | dipeptidyl peptidase | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | periodontopathic bacteria | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Porphyromonas gingivalis | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | saliva | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Ohara-Nemoto, Yuko
× Ohara-Nemoto, Yuko× Shimoyama, Yu× Nakasato, Manami× Nishimata, Haruka× Ishikawa, Taichi× Sasaki, Minoru× Kimura, Shigenobu× Nemoto, Takayuki K |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Dipeptidyl peptidase (DPP) 4, DPP5, DPP7, and DPP11, expressed in the periplasmic space, are crucial for energy production for Porphyromonas gingivalis, an asaccharolytic bacterium that causes periodontal disease. Bacterial DPP4 seems to be involved in regulation of blood glucose level via degradation of incretins. The present study aimed to identify four dpp orthologs in oral microbiota by database searches, and their enzymatic activities in periodontopathic and cariogenic bacteria, as well as oral specimens were determined. Search in the databases suggested that 43 species of 772 taxa possess dpp4 and other dpp genes. Most species are in the genera Bacteroides, Capnocytophaga, Porphyromonas, Prevotella, and Tannerella, indicating a limited distribution of dpp orthologs in anaerobic periodontopathic rods. In accordance with those results, activities of all four DPPs were demonstrated in P. gingivalis, Porphyromonas endodontalis, and Tannerella forsythia, while they were negligible in Treponema denticola, Fusobacterium nucleatum, and Aggregatibacter actinomycetemcomitans. Furthermore, DPP activities were also detected in subgingival dental plaque at different intensities among individual specimens, while DPP4 activity presumably derived from human entity was solely predominant in saliva samples. These findings demonstrated that DPP activities in dental plaque serve as potent biomarkers to indicate the presence of periodontopathic bacteria | |||||
書誌情報 |
FEMS Microbiology Letters 巻 365, 号 22, p. fny221, 発行日 2018-09-10 |
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出版者 | ||||||
出版者 | Oxford University Press | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 03781097 | |||||
EISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 15746968 | |||||
DOI | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1093/femsle/fny221 | |||||
権利 | ||||||
権利情報 | c FEMS 2018. This is a pre-copyedited, author-produced version of an article accepted for publication in FEMS Microbiology Letters following peer review. The version of record FEMS Microbiology Letters, 365(22), fny221 is available online at: https://doi.org/10.1093/femsle/fny221. | |||||
著者版フラグ | ||||||
出版タイプ | AM | |||||
出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | FEMS Microbiology Letters, 365(22), fny221; 2018 |