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Intracystic Papillary Carcinoma of Breast Harbors Significant Genomic Alteration Compared with Intracystic Papilloma: Genome-wide Copy Number and LOH Analysis Using High-Density Single-Nucleotide Polymorphism Microarrays.
http://hdl.handle.net/10069/25232
http://hdl.handle.net/10069/252324bf1226e-bc59-4668-ba05-9bf3b026a995
名前 / ファイル | ライセンス | アクション |
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BreJou17_427.pdf (658.0 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2011-06-14 | |||||
タイトル | ||||||
タイトル | Intracystic Papillary Carcinoma of Breast Harbors Significant Genomic Alteration Compared with Intracystic Papilloma: Genome-wide Copy Number and LOH Analysis Using High-Density Single-Nucleotide Polymorphism Microarrays. | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Intracystic papillary tumor | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | breast cancer | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | array CGH | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | GeneChip® | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | FFPE | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Oikawa, Masahiro
× Oikawa, Masahiro× Nagayasu, Takeshi× Yano, Hiroshi× Hayashi, Tomayoshi× Abe, Kuniko× Kinoshita, Akira× Yoshiura, Koh-Ichiro |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Purpose: Intracystic papillary breast tumors consist of benign papilloma, carcinoma in situ and carcinoma with invasion. Using high-density single-nucleotide polymorphism arrays, this study aimed to determine the profile of genomic alterations in these lesions and to identify novel diagnostic criteria. Methods: Ten samples of intracystic papillary tumor, which included five papillomas (Pap), three papillary carcinomas in situ (PurePC) and two papillary carcinomas with invasion (PCinv), were studied. DNA was extracted from tumor and normal tissues that were microdissected from the same formalin-fixed paraffin embedded blocks. Using probe intensity and genotype data from high-density oligonucleotide SNP microarrays (AffymetrixR GeneChip Genome-wide Human 5.0), paired copy number and LOH analysis was performed using Partek Genomic Suite Software. Results: Quality control (QC) call rate, which is an index measuring the quality of a SNP microarray experiment, ranged from 70.75% to 91.93%, mean 80.72%. The mean total genomic alteration rate (sum of amplifications, deletions and copy-neutral loss of heterogeneity) with respect to the whole genome was 2.87%, 15.4% and 35.3% in Pap, PC and IDC, respectively, and was significantly different between samples (Kruskal-Wallis chi-squared test, p = 0.043). The most commonly altered regions (. 4/5) in papillary carcinoma were copy-neutral loss of heterogeneity at 3p21.31 and 3p14.2 and amplification at 20q13.13. Genes altered only in invasive carcinoma included genes concerned with transcription. Conclusions: Among intracystic papillary breast tumors, malignant tumors, including non-invasive tumors, which are difficult to diagnose histopathologically, harbor significant genomic alteration. Our findings may aid clinical management of these tumors and may provide insight into their carcinogenesis. | |||||
書誌情報 |
The Breast Journal 巻 17, 号 4, p. 427-430, 発行日 2011-06-09 |
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出版者 | ||||||
出版者 | Wiley | |||||
EISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 15244741 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA11617799 | |||||
PubMed番号 | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | PMID | |||||
関連識別子 | 21651641 | |||||
DOI | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1111/j.1524-4741.2011.01110.x | |||||
権利 | ||||||
権利情報 | © 2011 Wiley Periodicals, Inc. | |||||
権利 | ||||||
権利情報 | This is the pre-peer reviewed version of the following article: Intracystic Papillary Carcinoma of Breast Harbors Significant Genomic Alteration Compared with Intracystic Papilloma: Genome-wide Copy Number and LOH Analysis Using High-Density Single-Nucleotide Polymorphism Microarrays, which has been published in final form at http://dx.doi.org/10.1111/j.1524-4741.2011.01110.x | |||||
著者版フラグ | ||||||
出版タイプ | AM | |||||
出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
関係URI | ||||||
関連名称 | http://hdl.handle.net/10069/25280 | |||||
関係URI | ||||||
関連名称 | http://hdl.handle.net/10069/26723 | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | The Breast Journal, 17(4), pp.427–430; 2011 |