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T cell and periosteum cooperation in osteoclastogenesis induced by lipopolysaccharide injection in transplanted?mouse tibia
http://hdl.handle.net/10069/38591
http://hdl.handle.net/10069/385917a252fcb-730d-42db-8b94-5d312872f28b
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
ISYK1080_Kobayashi.pdf (2.5 MB)
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| Item type | 学位論文 / Thesis or Dissertation(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2018-09-21 | |||||
| タイトル | ||||||
| タイトル | T cell and periosteum cooperation in osteoclastogenesis induced by lipopolysaccharide injection in transplanted?mouse tibia | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Osteoclastogenesis | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Periosteum | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Receptor activator of NF-kB ligand | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | T cells | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_db06 | |||||
| 資源タイプ | doctoral thesis | |||||
| アクセス権 | ||||||
| アクセス権 | open access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||
| 著者 |
小林, 弘樹
× 小林, 弘樹 |
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| 著者別名 | ||||||
| 識別子Scheme | WEKO | |||||
| 識別子 | 116178 | |||||
| 姓名 | Kobayashi, Hiroki | |||||
| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Background/purpose: We previously reported that injedctions of lipopolysaccharide (LPS) into the gingiva of mice induce inflammatory bone resorption that actively involved T cells. Receptor activator of NF-κB ligand (RANKL), which is an essential factor for osteoclastogenesis, was reportedly produced by osteoblasts, fibroblasts, and T cells in vitro; however, it has not been established which cells affect osteoclastogenesis in vivo. Here we determined the roles of T cells and the periosteum on osteoclastogenesis in LPS-induced inflammatory bone resorption. Materials and methods: Thirty-five BALB/c (wild-type: WT) and 10 BALB/c-nu/nu (nude: Nu) mice congenitally lacking T cells were used. Using inbred WT mice, tibias were transplanted with and without the periostea [(+) and (?), respectively, n = 15 per group] into the dorsal subcutaneous connective tissue of WT or Nu mice. Each group received four injections around the transplanted site: experimental groups were injected with LPS, and control groups were injected with phosphate-buffered saline. Isolated tissues were prepared for histopathological observation of the transplanted bone surface. Results: Many infiltrating inflammatory cells were present near the surface of the tibias in the LPS-injected groups. Only the WT (+) LPS group showed osteoclasts. The number of mononuclear preosteoclasts and RANKL-positive cells was highest in the WT (+) LPS group, and there were no significant differences among the other three groups. Conclusion: T cells and the periosteum are closely involved in osteoclastogenesis in inflammatory bone resorption in vivo. | |||||
| 内容記述 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | 長崎大学学位論文 学位記番号:博(医歯薬)甲第1080号 学位授与年月日:平成30年6月6日 | |||||
| 内容記述 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | Author: Hiroki Kobayashi, Takashi Ukai, Chiaki Shiraishi, Yukio Ozaki, Atsutoshi Yoshimura, Yoshitaka Hara | |||||
| 内容記述 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | Citation: Journal of Dental Sciences, 13(3), pp.226-233; 2018 | |||||
| 書誌情報 |
Journal of Dental Sciences 巻 13, 号 3, p. 226-233, 発行日 2018-06-06 |
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| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 19917902 | |||||
| DOI | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.1016/j.jds.2018.03.001 | |||||
| 権利 | ||||||
| 権利情報 | c 2018 Association for Dental Sciences of the Republic of China. Publishing services by Elsevier B.V. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). | |||||
| 著者版フラグ | ||||||
| 出版タイプ | VoR | |||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
| その他のタイトル | ||||||
| その他のタイトル | 移植したマウス脛骨へのリポ多糖の注入により誘導される破骨細胞形成におけるT細胞と骨膜の協調 | |||||
| 出版者 | ||||||
| 出版者 | Association for Dental Sciences of The Republic of China | |||||
| 関係URI | ||||||
| 識別子タイプ | HDL | |||||
| 関連識別子 | http://hdl.handle.net/10069/38355 | |||||
| 学位名 | ||||||
| 学位名 | 博士(歯学) | |||||
| 学位授与機関 | ||||||
| 学位授与機関識別子Scheme | kakenhi | |||||
| 学位授与機関識別子 | 17301 | |||||
| 学位授与機関名 | Nagasaki University (長崎大学) | |||||
| 学位授与年月日 | ||||||
| 学位授与年月日 | 2018-06-06 | |||||
| 学位授与番号 | ||||||
| 学位授与番号 | 甲医歯薬第1080号 | |||||
| 学位の種類 | ||||||
| 値 | 課程博士 | |||||
| 引用 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | Nagasaki University (長崎大学), 博士(歯学) (2018-06-06) | |||||
