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Studies have found evidence that smoking cessation is associated with weight gain, which is itself a leading cause of cardiovascular disease. Aim The present study sought to determine how smoking cessation and associated weight gain affect adiponectin levels and insulin resistance. Methods Fifty-two male habitual smokers were treated for 2 months with transdermal nicotine patches, and the 28 subjects who successfully quit smoking were analyzed. Subjects were divided into two sub-groups according to their weight change: weight maintainers and weight gainers. Serum adiponectin levels and the homeostasis model assessment ratio (HOMA-R) were evaluated at the beginning of the study, and at 1 week and 9 weeks after cessation of patch use. Results In weight gainers (n=18), serum adiponection levels tended to increase at 1 week after the end of treatment (mean difference 0.4±1.0 μg/mL, p=0.08). Moreover, after 9 weeks, adiponectin levels were significantly decreased in weight gainers (mean difference between 1 week and 9 weeks 0.8±0.9 μg/mL, p=0.002). In weight maintainers, adiponectin levels increased slightly after smoking cessation, but changes were not significant. In weight gainers, HOMA-R index was significantly increased (mean difference between baseline and 9 weeks 0.4±0.7, p=0.01), while in weight maintainers, HOMA-R index showed no differences throughout the study. 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Early Effects of Smoking Cessation and Weight Gain on Plasma Adiponectin Levels and Insulin Resistance
http://hdl.handle.net/10069/25426
http://hdl.handle.net/10069/254268f93bb02-a995-4c2f-a92a-5657aa23e906
名前 / ファイル | ライセンス | アクション |
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IntMed50_707.pdf (140.0 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2011-07-28 | |||||
タイトル | ||||||
タイトル | Early Effects of Smoking Cessation and Weight Gain on Plasma Adiponectin Levels and Insulin Resistance | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Adiponectin | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Insulin resistance | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Smoking cessation | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Weight gain | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Inoue, Keita
× Inoue, Keita× Takeshima, Fuminao× Kadota, Koichiro× Yoda, Aya× Tatsuta, Yoichi× Nagaura, Yuki× Yoshioka, Sumako× Nakamichi, Seiko× Nakao, Kazuhiko× Ozono, Yoshiyuki |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Background Tobacco smoking is a major risk factor for atherosclerotic and cardiovascular disease. Studies have found evidence that smoking cessation is associated with weight gain, which is itself a leading cause of cardiovascular disease. Aim The present study sought to determine how smoking cessation and associated weight gain affect adiponectin levels and insulin resistance. Methods Fifty-two male habitual smokers were treated for 2 months with transdermal nicotine patches, and the 28 subjects who successfully quit smoking were analyzed. Subjects were divided into two sub-groups according to their weight change: weight maintainers and weight gainers. Serum adiponectin levels and the homeostasis model assessment ratio (HOMA-R) were evaluated at the beginning of the study, and at 1 week and 9 weeks after cessation of patch use. Results In weight gainers (n=18), serum adiponection levels tended to increase at 1 week after the end of treatment (mean difference 0.4±1.0 μg/mL, p=0.08). Moreover, after 9 weeks, adiponectin levels were significantly decreased in weight gainers (mean difference between 1 week and 9 weeks 0.8±0.9 μg/mL, p=0.002). In weight maintainers, adiponectin levels increased slightly after smoking cessation, but changes were not significant. In weight gainers, HOMA-R index was significantly increased (mean difference between baseline and 9 weeks 0.4±0.7, p=0.01), while in weight maintainers, HOMA-R index showed no differences throughout the study. Conclusion Our findings suggest that the adverse effects of weight gain attenuate some of the beneficial effects of smoking cessation. | |||||
書誌情報 |
Internal Medicine 巻 50, 号 7, p. 707-712, 発行日 2011-04-01 |
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出版者 | ||||||
出版者 | 日本内科学会 | |||||
出版者別言語 | ||||||
The Japanese Society of Internal Medicine | ||||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 09182918 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA10827774 | |||||
DOI | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.2169/internalmedicine.50.4600 | |||||
権利 | ||||||
権利情報 | Copyright (c) 2011 by The Japanese Society of Internal Medicine | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
関係URI | ||||||
関連名称 | http://hdl.handle.net/10069/26687 | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Internal Medicine, 50(7), pp.707-712; 2011 |