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Pharmacodynamic interactions between MDMA and concomitants in MDMA tablets on extracellular dopamine and serotonin in the rat brain.
http://hdl.handle.net/10069/25453
http://hdl.handle.net/10069/25453ce3d31dc-9ccd-4c4d-a8d9-d7fa15b9fe8c
名前 / ファイル | ライセンス | アクション |
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EJP660_318.pdf (689.8 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2011-08-02 | |||||
タイトル | ||||||
タイトル | Pharmacodynamic interactions between MDMA and concomitants in MDMA tablets on extracellular dopamine and serotonin in the rat brain. | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | 3,4-Methylenedioxymethamphetamine | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Caffeine | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Dopamine | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Interaction | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Ketamine | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Methamphetamine | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Serotonin | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Ikeda, Rie
× Ikeda, Rie× Igari, Yoshiko× Fuchigami, Yuki× Wada, Mitsuhiro× Kuroda, Naotaka× Nakashima, Kenichiro |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | 3,4-methylenedioxymethamphetamine (MDMA) is a psychoactive stimulant abused by young people as the recreational drug ecstasy. Other compounds, either deliberately added or present as byproducts, are often found in MDMA tablets and can unexpectedly interact with each other. The aim of this study was to evaluate the pharmacodynamic effects of interactions caused by concomitants in MDMA tablets on extracellular dopamine and serotonin (5-HT) by microdialysis in the striatum of ethylcarbamate-anesthetized rats. Baseline levels of dopamine and 5-HT in the striatum were 16.5±7.7 and 3.5±1.7 nM (mean±standard deviation), respectively. After a single administration of MDMA (10 mg/kg, i.p.), a dramatic increase in extracellular dopamine (Cmax: 36.1-fold vs. baseline) and 5-HT levels (Cmax: 9.3-fold vs. baseline) was observed. When rats were co-administered with methamphetamine (1, 5 or 10 mg/kg) with MDMA, the dopamine levels induced by MDMA increased in a methamphetamine-dose-dependent manner (Cmax: 2.5-, 3.5-, and 3.8-fold vs. MDMA). A similar trend was observed in 5-HT levels (Cmax: 1.1-, 1.3-, and 1.8-fold vs. MDMA). In contrast, ketamine and caffeine showed synergistic effects on the monoamine levels induced by MDMA, whereas the individual administration of either of these compounds did not affect monoamine levels. Ketamine (1, 5 mg/kg) decreased the dopamine levels induced by MDMA (Cmax: 0.9- and 0.7-fold vs. MDMA) and increased the 5-HT levels induced by MDMA (Cmax: 1.4- and 1.6-fold vs. MDMA), and co-administration of caffeine (20 mg/kg) with MDMA increased dopamine levels (Cmax: 1.7-fold vs. MDMA). These results suggest that exposure to multiple drugs in addition to MDMA can have neurotoxic effects. | |||||
書誌情報 |
European Journal of Pharmacology 巻 660, 号 2-3, p. 318-325, 発行日 2011-06-25 |
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出版者 | ||||||
出版者 | Elsevier B.V. | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 00142999 | |||||
EISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 18790712 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA00639687 | |||||
PubMed番号 | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | PMID | |||||
関連識別子 | 21497593 | |||||
DOI | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1016/j.ejphar.2011.03.050 | |||||
権利 | ||||||
権利情報 | Copyright © 2011 Elsevier B.V. All rights reserved. | |||||
著者版フラグ | ||||||
出版タイプ | AM | |||||
出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | European Journal of Pharmacology, 660(2-3), pp.318-325; 2011 |