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Anti-thyroid peroxidase antibody and subclinical hypothyroidism in relation to hypertension and thyroid cysts
http://hdl.handle.net/10069/40363
http://hdl.handle.net/10069/403634768fb76-78e3-4dac-8c62-99028d2f5f9a
名前 / ファイル | ライセンス | アクション |
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PLoS15_0240198.pdf (808.7 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2020-10-23 | |||||
タイトル | ||||||
タイトル | Anti-thyroid peroxidase antibody and subclinical hypothyroidism in relation to hypertension and thyroid cysts | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Shimizu, Yuji
× Shimizu, Yuji× Kawashiri, Shin-Ya× Noguchi, Yuko× Nagata, Yasuhiro× Maeda, Takahiro× Hayashida, Naomi |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Hypertension frequently occurs in subclinical hypothyroidism(SCH).By bolstering thyroid inflammation, anti-peroxidase antibody(TPO-Ab) causes autoimmune thyroiditis, which is one of the most common causes of SCH. Since the absence of thyroid cysts is associated with TPO-Ab (+) based on the indication of latent thyroid damage, we explored the potential mechanism underlying the association among TPO-Ab, SCH, hypertension, and thyroid cysts. A cross-sectional study of 1,483 Japanese aged 40-74 years was conducted. Thyroid cysts were defined as those having a maximum diameter of ? 2.0 mm, containing no solid component. TPO-Ab (+) was positively associated with SCH with hypertension (adjusted odds ratio [OR] and 95% confidence interval [CI], 2.62 [1.40, 4.89]) but not with SCH without hypertension (0.84 [0.37, 1.89]), respectively. Moreover, among participants without thyroid cysts, SCH was positively associated with hypertension (2.15 [1.23, 3.76]) but not among participants with thyroid cysts (0.58 [0.16, 2.16]), respectively. TPO-Ab was positively associated with SCH with hypertension, but not with SCH without hypertension. In addition, status of thyroid cysts might act as a determinant factor on the association between SCH and hypertension. These findings are efficient tools to clarify the background mechanism that underlies SCH. | |||||
書誌情報 |
PLOS ONE 巻 15, 号 10, p. e0240198, 発行日 2020-10-02 |
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出版者 | ||||||
出版者 | Public Library of Science | |||||
EISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 19326203 | |||||
DOI | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1371/journal.pone.0240198 | |||||
権利 | ||||||
権利情報 | c 2020 Shimizuet al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | PLoS ONE, 15(10), art.no.e0240198; 2020 |