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Characterization of a Novel Proteinous Toxin from Sea Anemone Actineria villosa.
http://hdl.handle.net/10069/25469
http://hdl.handle.net/10069/2546970f810da-a9fd-4851-ab0c-c08183440c70
名前 / ファイル | ライセンス | アクション |
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protein-j_2011_uechi.pdf (895.0 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2011-08-03 | |||||
タイトル | ||||||
タイトル | Characterization of a Novel Proteinous Toxin from Sea Anemone Actineria villosa. | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Actineria villosa | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Avt120 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | ATP degradation activity | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Ganglioside | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Cytotoxic | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Uechi, Gen-Ichiro
× Uechi, Gen-Ichiro× Toma, Hiromu× Arakawa, Takeshi× Sato, Yoshiya |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | The sea anemone Actineria villosa expresses a lethal protein toxin. We isolated a novel 120-kDa protein, Avt120, from partially purified toxin and found it to possess extremely strong lethal activity. The 3,453-bp Avt120 gene translates to a 995-amino acid protein. The 50% lethal dose (LD(50)) of purified Avt120 in mice was 85.17 ng. Among several tested cell lines, Colo205 cells were most sensitive to Avt120: 50% of them were damaged by 38.4 ng/mL Avt120. Avt120 exerted ATP degradation activity (10 μmol ATP h(-1) mg(-1)), which was strongly inhibited by ganglioside GM1 to decrease the cytotoxicity of Avt120. | |||||
書誌情報 |
The Protein Journal 巻 30, 号 6, p. 422-428, 発行日 2011-08 |
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ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 1875-8355 | |||||
PubMed番号 | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | PMID | |||||
関連識別子 | 21769623 | |||||
DOI | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1007/s10930-011-9347-8 | |||||
著者版フラグ | ||||||
出版タイプ | AM | |||||
出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | The Protein Journal, 30(6), pp.422-428; 2011 |