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False-Positive Accumulation of Metaiodobenzylguanidine in a Case with Acute Intermittent Porphyria
http://hdl.handle.net/10069/25470
http://hdl.handle.net/10069/2547034eebe08-a6ce-4c63-a634-7243e12d4fad
名前 / ファイル | ライセンス | アクション |
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IntMed50_1029.pdf (702.6 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2011-08-04 | |||||
タイトル | ||||||
タイトル | False-Positive Accumulation of Metaiodobenzylguanidine in a Case with Acute Intermittent Porphyria | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Acute intermittent porphyria | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | False-positive | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | MIBG | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Pheochromocytoma | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Masuda, Tomoko
× Masuda, Tomoko× Ota, Rie× Ando, Takao× Maeda, Naoto× Horie, Yutaka× Yoshimura, Toshiro× Motomura, Masakatsu× Kawakami, Atsushi |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | We report a 36-year-old woman presenting with hypertensive encephalopathy followed by bulbar palsy and quadriplegia. After an extensive screening for secondary causes of hypertension, the patient was suspected of having pheochromocytoma due to increased levels of catecholamines in the plasma and the urine, and positive 131I-metaiodobenzylguanidine (MIBG) accumulation in the gallbladder. However, MIBG accumulation was not reproducible without any tumors accompanying this accumulation in the gallbladder. A diagnosis of acute intermittent porphyria was finally confirmed based on the characteristic pictures, increased urinary excretion of porphobilinogen, and identification of a heterozygous missense mutation of R173W in the hydroxymethylbilane synthase gene. This case highlights a pitfall in utilizing MIBG to detect a source of excessive catecholamine and also suggests the importance of having a complete clinical history and extensive work-up of any possible differential diagnosis. We also review the potential mechanism by which falsepositive MIBG accumulation occurs. | |||||
書誌情報 |
Internal Medicine 巻 50, 号 9, p. 1029-1032, 発行日 2011-05-01 |
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出版者 | ||||||
出版者 | The Japanese Society of Internal Medicine | |||||
出版者別言語 | ||||||
日本内科学会 | ||||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 09182918 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA10827774 | |||||
DOI | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.2169/internalmedicine.50.5096 | |||||
権利 | ||||||
権利情報 | Copyright (c) 2011 by The Japanese Society of Internal Medicine | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Internal Medicine, 50(9), pp.1029-1032; 2011 |