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Potent amyloidogenicity and pathogenicity of Aβ43.
http://hdl.handle.net/10069/27387
http://hdl.handle.net/10069/2738703c6a123-00db-41b4-b192-dcc5a452eaf4
名前 / ファイル | ライセンス | アクション |
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NatNeu14_1023.pdf (686.4 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2012-03-01 | |||||
タイトル | ||||||
タイトル | Potent amyloidogenicity and pathogenicity of Aβ43. | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Saito, Takashi
× Saito, Takashi× Suemoto, Takahiro× Brouwers, Nathalie× Sleegers, Kristel× Funamoto, Satoru× Mihira, Naomi× Matsuba, Yukio× Yamada, Kazuyuki× Nilsson, Per× Takano, Jiro× Nishimura, Masaki× Iwata, Nobuhisa× Van, Broeckhoven Christine× Ihara, Yasuo× Saido, Takaomi C |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | The amyloid-β peptide Aβ42 is known to be a primary amyloidogenic and pathogenic agent in Alzheimer's disease. However, the role of Aβ43, which is found just as frequently in the brains of affected individuals, remains unresolved. We generated knock-in mice containing a pathogenic presenilin-1 R278I mutation that causes overproduction of Aβ43. Homozygosity was embryonic lethal, indicating that the mutation involves a loss of function. Crossing amyloid precursor protein transgenic mice with heterozygous mutant mice resulted in elevated Aβ43, impairment of short-term memory and acceleration of amyloid-β pathology, which accompanied pronounced accumulation of Aβ43 in plaque cores similar in biochemical composition to those observed in the brains of affected individuals. Consistently, Aβ43 showed a higher propensity to aggregate and was more neurotoxic than Aβ42. Other pathogenic presenilin mutations also caused overproduction of Aβ43 in a manner correlating with Aβ42 and with the age of disease onset. These findings indicate that Aβ43, an overlooked species, is potently amyloidogenic, neurotoxic and abundant in vivo. | |||||
書誌情報 |
Nature Neuroscience 巻 14, 号 8, p. 1023-1032, 発行日 2011-08 |
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出版者 | ||||||
出版者 | Nature Publishing Group | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 10976256 | |||||
EISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 15461726 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA11202192 | |||||
PubMed番号 | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | PMID | |||||
関連識別子 | 21725313 | |||||
DOI | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1038/nn.2858 | |||||
権利 | ||||||
権利情報 | © 2011 Nature America, Inc. All rights reserved. | |||||
著者版フラグ | ||||||
出版タイプ | AM | |||||
出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Nature Neuroscience, 14(8), pp.1023-1032; 2011 |