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Heat shock protein 47: a novel biomarker of phenotypically altered collagen-producing cells.
http://hdl.handle.net/10069/25615
http://hdl.handle.net/10069/25615ceea8a56-19bb-448c-9884-5adef0d37fe9
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
AHC44_35.pdf (1.4 MB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2011-08-31 | |||||
| タイトル | ||||||
| タイトル | Heat shock protein 47: a novel biomarker of phenotypically altered collagen-producing cells. | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Biomarker | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Collagen | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Fibrosis | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | HSP47 | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| 著者 |
Taguchi, Takashi
× Taguchi, Takashi× Nazneen, Arifa× Al-Shihri, Abdulmonem A× Turkistani, Khadijah A× Razzaque, Mohammed S |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Heat shock protein 47 (HSP47) is a collagen-specific molecular chaperone that helps the molecular maturation of various types of collagens. A close association between increased expression of HSP47 and the excessive accumulation of collagens is found in various human and experimental fibrotic diseases. Increased levels of HSP47 in fibrotic diseases are thought to assist in the increased assembly of procollagen, and thereby contribute to the excessive deposition of collagens in fibrotic areas. Currently, there is not a good universal histological marker to identify collagen-producing cells. Identifying phenotypically altered collagen-producing cells is essential for the development of cell-based therapies to reduce the progression of fibrotic diseases. Since HSP47 has a single substrate, which is collagen, the HSP47 cellular expression provides a novel universal biomarker to identify phenotypically altered collagen-producing cells during wound healing and fibrosis. In this brief article, we explained why HSP47 could be used as a universal marker for identifying phenotypically altered collagen-producing cells. | |||||
| 書誌情報 |
Acta Histochemica et Cytochemica 巻 44, 号 2, p. 35-41, 発行日 2011-04-28 |
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| 出版者 | ||||||
| 出版者 | The Japan Society of Histochemistry and Cytochemistry | |||||
| 出版者別言語 | ||||||
| 値 | 日本組織細胞化学会 | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 00445991 | |||||
| EISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 13475800 | |||||
| 書誌レコードID | ||||||
| 収録物識別子タイプ | NCID | |||||
| 収録物識別子 | AA00508022 | |||||
| PubMed番号 | ||||||
| 関連タイプ | isIdenticalTo | |||||
| 識別子タイプ | PMID | |||||
| 関連識別子 | 21614164 | |||||
| DOI | ||||||
| 関連タイプ | isIdenticalTo | |||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.1267/ahc.11001 | |||||
| 権利 | ||||||
| 権利情報 | Copyright (c) 2011 By the Japan Society of Histochemistry and Cytochemistry | |||||
| 著者版フラグ | ||||||
| 出版タイプ | VoR | |||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
| 引用 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | Acta Histochemica et Cytochemica, 44(2), pp.35-41; 2011 | |||||
