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Effects of continuous passive motion on the expression of membrane type 1-matrix metalloproteinase in rat immobilized muscles
http://hdl.handle.net/10069/25627
http://hdl.handle.net/10069/256278e27e45a-7f64-4b76-9763-19ba3f47d122
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
hokenn23_2_1.pdf (260.6 kB)
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| Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
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| 公開日 | 2011-08-31 | |||||
| タイトル | ||||||
| タイトル | Effects of continuous passive motion on the expression of membrane type 1-matrix metalloproteinase in rat immobilized muscles | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Membrane type 1 matrix metalloproteinase(MT1-MMP) | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | matrix metalloproteinase 2(MMP-2) | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | rat | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | muscle | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | continuous passive motion(CPM) | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | departmental bulletin paper | |||||
| 著者 |
Origuchi, Tomoki
× Origuchi, Tomoki× Sakai, Takayuki× Sakamoto, Junya× Nakano, Jiro× Okita, Minoru× Yoshimura, Toshiro× Eguchi, Katsumi× Kawakami, Atsushi |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | We examined the effects of continuous passive motion（ CPM） on membrane type 1-matrix metalloproteinase（ MT1-MMP） expression in rat immobilized muscles. Eight-week-old male Wister rats were used for each of two trials, one with 2 weeks, and another one with 4 weeks of immobilization with/without CPM. In each trial, rats were immobilized（ immobilization group）, and immobilized and simultaneously given CPM （CPM group）. The soleus muscle of each rat was evaluated by gelatin zymography, western blotting and reverse transcription-polymerase chain reaction（ RT-PCR）. Gelatin zymography revealed a greater level of gelatinase activity in the extract of the muscles of the immobilization group than in those of the control and CPM group. The expressions of matrix metalloproteinase 2 （MMP-2） and MT1-MMP mRNA in the muscle extract of the immobilization group were also greater than those in the control and CPM group. Our results suggested that joint immobilization induces expression of MT1-MMP, a cleavage enzyme of MMP-2 in muscles, resulting in muscular degeneration, and that CPM can prevent these changes. | |||||
| 書誌情報 |
保健学研究 en : Health Science Research 巻 23, 号 2, p. 1-6, 発行日 2011 |
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| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 18814441 | |||||
| 書誌レコードID | ||||||
| 収録物識別子タイプ | NCID | |||||
| 収録物識別子 | AA12200909 | |||||
| 著者版フラグ | ||||||
| 出版タイプ | VoR | |||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
| 出版者 | ||||||
| 出版者 | 長崎大学 | |||||
| 出版者別言語 | ||||||
| 値 | Nagasaki University | |||||
| sortkey | ||||||
| 値 | 01 | |||||
| 引用 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | 保健学研究, 23(2), pp.1-6; 2011 | |||||
