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Anti-inflammatory effects of garenoxacin on IL-8 production and ERK1/2 activation induced by lipopolysaccharides in A549 and THP-1 cells.
http://hdl.handle.net/10069/25733
http://hdl.handle.net/10069/2573338ab24e7-7aa9-4950-ad8f-98820c39a4a3
名前 / ファイル | ライセンス | アクション |
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EJP668_264.pdf (497.3 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2011-09-12 | |||||
タイトル | ||||||
タイトル | Anti-inflammatory effects of garenoxacin on IL-8 production and ERK1/2 activation induced by lipopolysaccharides in A549 and THP-1 cells. | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Fluoroquinolone | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Immunomodulatory effect | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Inflammatory cytokine | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Macrolide | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | MAPK phosphorylation | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Hara, Shintaro
× Hara, Shintaro× Ishimatsu, Yuji× Mukae, Hiroshi× Sakamoto, Noriho× Kakugawa, Tomoyuki× Fujita, Hanako× Hara, Atsuko× Kohno, Shigeru |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | The anti-inflammatory properties of macrolides have been applied to the treatment of inflammatory airway diseases. Although the anti-inflammatory properties of fluoroquinolones have been reported, no reports are available regarding a newly developed fluoroquinolone, garenoxacin (GRNX). To examine the immunomodulatory effect of GRNX, we examined the transcription and secretion of inflammatory cytokines by human airway epithelial cells and monocytes stimulated with lipopolysaccharide (LPS). A human lung epithelial cell line (A549) and a human monocyte cell line (THP-1) were stimulated with LPS and exposed to different concentrations of GRNX. The transcription and secretion of interleukin 8 (IL-8) in both A549 and THP-1 cells was measured by real-time PCR and an enzyme-linked immunosorbent assay, respectively. Treatment with GRNX significantly inhibited the transcription and secretion of IL-8 induced by LPS-stimulated cells through inhibitory ERK1/2 phosphorylation. GRNX has anti-inflammatory activity through its capacity to alter the secretion of IL-8 from A549 and THP-1 cell lines. Our findings suggest that GRNX is suitable for the treatment of LPS-induced respiratory infection and inflammatory airway diseases. | |||||
書誌情報 |
European Journal of Pharmacology 巻 668, 号 1-2, p. 264-270, 発行日 2011-10-01 |
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出版者 | ||||||
出版者 | Elsevier BV | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 00142999 | |||||
EISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 18790712 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA00639687 | |||||
PubMed番号 | ||||||
識別子タイプ | PMID | |||||
関連識別子 | 21762685 | |||||
DOI | ||||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1016/j.ejphar.2011.06.046 | |||||
権利 | ||||||
権利情報 | Copyright © 2011 Elsevier B.V. All rights reserved. | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | European Journal of Pharmacology, 668(1-2), pp.264-270; 2011 |