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Novel Epitopic Region of Glucosyltransferase B from Streptococcus mutans.
http://hdl.handle.net/10069/27399
http://hdl.handle.net/10069/27399b0d67755-04d2-4fbf-8d5c-8c1550eae23a
名前 / ファイル | ライセンス | アクション |
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CVI18_1552.pdf (1.1 MB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2012-04-01 | |||||
タイトル | ||||||
タイトル | Novel Epitopic Region of Glucosyltransferase B from Streptococcus mutans. | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | glucosyltransferase B | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | dental caries | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | antigenicity | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | DNA vaccine | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | adenovirus | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Hoshino, Tomonori
× Hoshino, Tomonori× Kondo, Yoshio× Saito, Kan× Terao, Yutaka× Okahashi, Nobuo× Kawabata, Shigetada× Fujiwara, Taku |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | In the development of a component vaccine against caries, the catalytic region (CAT) and glucan-binding domain (GBD) of glucosyltransferase B (GtfB) from Streptococcus mutans have been employed as target antigens. These regions were adopted as primary targets because they theoretically include epitopes associated with enzyme function. However, their antigenicities have not been fully evaluated. Although there are many reports about successful vaccination using these components, the principle has not yet been put to practical use. For these reasons, we came to doubt the effectiveness of the epitopes in vaccine production and reevaluated the antigenic region of GtfB by using in silico analyses combined with in vitro and in vivo experiments. The results suggested that the ca. 360-amino-acid variable region (VR) in the N terminus of GtfB is more reactive than CAT and GBD. This region is S. mutans and/or GtfB specific, nonconserved among other streptococcal Gtfs, and of unknown function. Immunization using an adenovirus vector-borne DNA vaccine confirmed that VR is an epitope that shows promise for the development of a caries vaccine. | |||||
書誌情報 |
Clinical and Vaccine Immunology : CVI 巻 18, 号 9, p. 1552-1561, 発行日 2011-09 |
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出版者 | ||||||
出版者 | American Society for Microbiology. | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 15566811 | |||||
EISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 1556679X | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA12127401 | |||||
PubMed番号 | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | PMID | |||||
関連識別子 | 21795464 | |||||
DOI | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1128/CVI.05041-11 | |||||
権利 | ||||||
権利情報 | Copyright © 2011, American Society for Microbiology. All Rights Reserved. | |||||
著者版フラグ | ||||||
出版タイプ | AM | |||||
出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Clinical and Vaccine Immunology, 18(9), pp.1552-1561; 2011 |