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Imaging mass spectrometry analysis reveals an altered lipid distribution pattern in the tubular areas of hyper-IgA murine kidneys.
http://hdl.handle.net/10069/25854
http://hdl.handle.net/10069/25854251611da-8c37-482b-8ca8-c04e0c33d2a9
名前 / ファイル | ライセンス | アクション |
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EMP91_614.pdf (1.6 MB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2011-09-26 | |||||
タイトル | ||||||
タイトル | Imaging mass spectrometry analysis reveals an altered lipid distribution pattern in the tubular areas of hyper-IgA murine kidneys. | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Deposition | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | IgA | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Imaging mass spectrometry | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Lipid | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Molecular distribution | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Molecular imaging | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Nephropathy | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Phosphatidylcholine | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Urinary stagnation | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Urine | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Kaneko, Yukihiro
× Kaneko, Yukihiro× Obata, Yoko× Nishino, Tomoya× Kakeya, Hiroshi× Miyazaki, Yoshitsugu× Hayasaka, Takahiro× Setou, Mitsutoshi× Furusu, Akira× Kohno, Shigeru |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Immunoglobulin A (IgA) nephropathy is the most common glomerular disease worldwide. To investigate the pathogenesis of this renal disease, we used animal models that spontaneously develop mesangioproliferative lesions with IgA deposition, which closely resemble the disease in humans. We analyzed the molecular distribution of lipids in hyper-IgA (HIGA) murine kidneys using matrix-assisted laser desorption/ionization-quadrupole ion trap-time of flight (MALDI-QIT-TOF)-based imaging mass spectrometry (IMS), which supplies both spatial distribution of the detected molecules and allows identification of their structures by their molecular mass signature. For both HIGA and control (Balb/c) mice, we found two phosphatidylcholines, PC(16:0/22:6) and PC(18:2/22:6), primarily located in the cortex area and two triacylglycerols, TAG(16:0/18:2/18:1) and TAG(18:1/18:2/18:1), primarily located in the hilum area. However, several other molecules were specifically seen in the HIGA kidneys, particularly in the tubular areas. Two HIGA-specific molecules were O-phosphatidylcholines, PC(O-16:0/22:6) and PC(O-18:1/22:6). Interestingly, common phosphatidylcholines and these HIGA-specific ones possess 22:6 lipid side chains, suggesting that these molecules have a novel, unidentified renal function. Although the primary structure of the HIGA-specific molecules corresponding to m/z 854.6, 856.6, 880.6, and 882.6 remained undetermined, they shared similar fragmentation patterns, indicating their relatedness. We also showed that all the HIGA-specific molecules were derived from urine, and that artificial urinary stagnation-due to unilateral urethral obstruction-caused HIGA-specific distribution of lipids in the tubular area. | |||||
書誌情報 |
Experimental and Molecular Pathology 巻 91, 号 2, p. 614-621, 発行日 2011-07-23 |
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出版者 | ||||||
出版者 | Elsevier Inc. | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 00144800 | |||||
EISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 10960945 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA00641168 | |||||
PubMed番号 | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | PMID | |||||
関連識別子 | 21798258 | |||||
DOI | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1016/j.yexmp.2011.07.002 | |||||
権利 | ||||||
権利情報 | Copyright © 2011 Elsevier Inc. All rights reserved. | |||||
著者版フラグ | ||||||
出版タイプ | AM | |||||
出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Experimental and Molecular Pathology, 91(2), pp.614-621; 2011 |