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The FOXE1 locus is a major genetic determinant for radiation-related thyroid carcinoma in Chernobyl.
http://hdl.handle.net/10069/25394
http://hdl.handle.net/10069/25394daff61f1-7d51-4716-aee0-106ffff0fcce
名前 / ファイル | ライセンス | アクション |
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HMG19_2516.pdf (1.1 MB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2011-07-25 | |||||
タイトル | ||||||
タイトル | The FOXE1 locus is a major genetic determinant for radiation-related thyroid carcinoma in Chernobyl. | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Takahashi, Meiko
× Takahashi, Meiko× Saenko, Vladimir A× Rogounovitch, Tatiana I× Kawaguchi, Takahisa× Drozd, Valentina M× Takigawa-Imamura, Hisako× Akulevich, Natallia M× Ratanajaraya, Chanavee× Mitsutake, Norisato× Takamura, Noboru× Danilova, Larisa I× Lushchik, Maxim L× Demidchik, Yuri E× Heath, Simon× Yamada, Ryo× Lathrop, Mark× Matsuda, Fumihiko× Yamashita, Shunichi |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Papillary thyroid cancer (PTC) among individuals exposed to radioactive iodine in their childhood or adolescence is a major internationally recognized health consequence of the Chernobyl accident. To identify genetic determinants affecting individual susceptibility to radiation-related PTC, we conducted a genome-wide association study employing Belarusian patients with PTC aged 0-18 years at the time of accident and age-matched Belarusian control subjects. Two series of genome scans were performed using independent sample sets, and association with radiation-related PTC was evaluated. Meta-analysis by the Mantel-Haenszel method combining the two studies identified four SNPs at chromosome 9q22.33 showing significant associations with the disease (Mantel-Haenszel P: mhp = 1.7 x 10(-9) to 4.9 x 10(-9)). The association was further reinforced by a validation analysis using one of these SNP markers, rs965513, with a new set of samples (overall mhp = 4.8 x 10(-12), OR = 1.65, 95% CI: 1.43-1.91). Rs965513 is located 57-kb upstream to FOXE1, a thyroid-specific transcription factor with pivotal roles in thyroid morphogenesis and was recently reported as the strongest genetic risk marker of sporadic PTC in European populations. Of interest, no association was obtained between radiation-related PTC and rs944289 (mhp = 0.17) at 14p13.3 which showed the second strongest association with sporadic PTC in Europeans. These results show that the complex pathway underlying the pathogenesis may be partly shared by the two etiological forms of PTC, but their genetic components do not completely overlap each other, suggesting the presence of other unknown etiology-specific genetic determinants in radiation-related PTC. | |||||
書誌情報 |
Human molecular genetics 巻 19, 号 12, p. 2516-2523, 発行日 2010-06-15 |
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出版者 | ||||||
出版者 | Oxford University Press | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 09646906 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA10836720 | |||||
PubMed番号 | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | PMID | |||||
関連識別子 | 20350937 | |||||
DOI | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1093/hmg/ddq123 | |||||
権利 | ||||||
権利情報 | © The Author 2010. Published by Oxford University Press. All rights reserved. | |||||
権利 | ||||||
権利情報 | This is a pre-copy-editing, author-produced PDF of an article accepted for publication in Human Molecular Genetics following peer review. The definitive publisher-authenticated version Human molecular genetics, 19(12), pp.2516-2523; 2010 is available online at: http://dx.doi.org/10.1093/hmg/ddq123. | |||||
著者版フラグ | ||||||
出版タイプ | AM | |||||
出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Human molecular genetics, 19(12), pp.2516-2523; 2010 |