WEKO3
アイテム
{"_buckets": {"deposit": "43c3e070-4ac2-4214-befb-bd129328ce87"}, "_deposit": {"created_by": 2, "id": "14088", "owners": [2], "pid": {"revision_id": 0, "type": "depid", "value": "14088"}, "status": "published"}, "_oai": {"id": "oai:nagasaki-u.repo.nii.ac.jp:00014088", "sets": ["9"]}, "author_link": ["50616", "50615", "50619", "50614", "50617", "50618", "50610", "50612", "50611", "50613", "50609"], "item_2_biblio_info_6": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2010-09", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "7", "bibliographicPageEnd": "419", "bibliographicPageStart": "411", "bibliographicVolumeNumber": "36", "bibliographic_titles": [{"bibliographic_title": "Experimental Lung Research"}]}]}, "item_2_description_4": {"attribute_name": "抄録", "attribute_value_mlt": [{"subitem_description": "alpha-Defensins, antimicrobial peptides produced mainly by neutrophils, have been reported to be associated with a wide variety of lung diseases, including idiopathic pulmonary fibrosis (IPF), cystic fibrosis (CF), and diffuse panbronchiolitis (DPB). In each disease, alpha-defensins are located in different areas, such as around the alveolar septa in IPF and around the airways in CF and DPB, suggesting that alpha-defensins play different roles. Meanwhile, growth factors are known to contribute to IPF, CF, and DPB. alpha-Defensins are known to induce interleukin (IL)-8 in airway epithelial cells, but the effects of alpha-defensins on the release of growth factors from various components in the lung have not been sufficiently investigated. In the present study, the in vitro effects of human neutrophil peptide (HNP)-1 (a subtype of alpha-defensin) on the expressions of IL-8 and growth factors in lung fibroblasts, bronchial epithelial cells, and alveolar epithelial cells were examined. HNP-1 mainly enhanced the expression of IL-8 in epithelial cells, whereas it enhanced transforming growth factor-beta and vascular endothelial growth factor expressions in lung fibroblasts. These results suggest that alpha-defensins play different roles in the pathogenesis of IPF, CF, and DPB according to the location in the lung where the alpha-defensins are mainly produced.", "subitem_description_type": "Abstract"}]}, "item_2_description_63": {"attribute_name": "引用", "attribute_value_mlt": [{"subitem_description": "Experimental Lung Research, 36(7), pp.411-419; 2010", "subitem_description_type": "Other"}]}, "item_2_relation_11": {"attribute_name": "PubMed番号", "attribute_value_mlt": [{"subitem_relation_type": "isVersionOf", "subitem_relation_type_id": {"subitem_relation_type_id_text": "20715983", "subitem_relation_type_select": "PMID"}}]}, "item_2_relation_12": {"attribute_name": "DOI", "attribute_value_mlt": [{"subitem_relation_type": "isVersionOf", "subitem_relation_type_id": {"subitem_relation_type_id_text": "10.3109/01902141003714049", "subitem_relation_type_select": "DOI"}}]}, "item_2_rights_13": {"attribute_name": "権利", "attribute_value_mlt": [{"subitem_rights": "© 2010 Informa Healthcare USA, Inc."}, {"subitem_rights": "This is an electronic version of an article published in Experimental lung research, 36(7), pp.411-419; 2010. Experimental lung research is available online at: http://informahealthcare.com/doi/abs/10.3109/01902141003714049"}]}, "item_2_source_id_10": {"attribute_name": "書誌レコードID", "attribute_value_mlt": [{"subitem_source_identifier": "AA00181680", "subitem_source_identifier_type": "NCID"}]}, "item_2_source_id_7": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "01902148", "subitem_source_identifier_type": "ISSN"}]}, "item_2_source_id_8": {"attribute_name": "EISSN", "attribute_value_mlt": [{"subitem_source_identifier": "15210499", "subitem_source_identifier_type": "ISSN"}]}, "item_2_version_type_16": {"attribute_name": "著者版フラグ", "attribute_value_mlt": [{"subitem_version_resource": "http://purl.org/coar/version/c_ab4af688f83e57aa", "subitem_version_type": "AM"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Amenomori, Misato"}], "nameIdentifiers": [{"nameIdentifier": "50609", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Mukae, Hiroshi"}], "nameIdentifiers": [{"nameIdentifier": "50610", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Ishimatsu, Yuji"}], "nameIdentifiers": [{"nameIdentifier": "50611", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Sakamoto, Noriho"}], "nameIdentifiers": [{"nameIdentifier": "50612", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Kakugawa, Tomoyuki"}], "nameIdentifiers": [{"nameIdentifier": "50613", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Hara, Atsuko"}], "nameIdentifiers": [{"nameIdentifier": "50614", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Hara, Shintaro"}], "nameIdentifiers": [{"nameIdentifier": "50615", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Fujita, Hanako"}], "nameIdentifiers": [{"nameIdentifier": "50616", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Ishimoto, Hiroshi"}], "nameIdentifiers": [{"nameIdentifier": "50617", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Hayashi, Tomayoshi"}], "nameIdentifiers": [{"nameIdentifier": "50618", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Kohno, Shigeru"}], "nameIdentifiers": [{"nameIdentifier": "50619", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2020-12-22"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "ELR36_411.pdf", "filesize": [{"value": "2.1 MB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_free", "mimetype": "application/pdf", "size": 2100000.0, "url": {"label": "ELR36_411.pdf", "url": "https://nagasaki-u.repo.nii.ac.jp/record/14088/files/ELR36_411.pdf"}, "version_id": "a420fab1-5f0d-4cca-9f51-9f19d92bcb81"}]}, "item_keyword": {"attribute_name": "キーワード", "attribute_value_mlt": [{"subitem_subject": "Epithelial cells", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Fibroblasts", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Human neutrophil peptide-1", "subitem_subject_scheme": "Other"}, {"subitem_subject": "KEYWORDS α-defensins", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "journal article", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "Differential effects of human neutrophil peptide-1 on growth factor and interleukin-8 production by human lung fibroblasts and epithelial cells.", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "Differential effects of human neutrophil peptide-1 on growth factor and interleukin-8 production by human lung fibroblasts and epithelial cells."}]}, "item_type_id": "2", "owner": "2", "path": ["9"], "permalink_uri": "http://hdl.handle.net/10069/25638", "pubdate": {"attribute_name": "公開日", "attribute_value": "2011-09-01"}, "publish_date": "2011-09-01", "publish_status": "0", "recid": "14088", "relation": {}, "relation_version_is_last": true, "title": ["Differential effects of human neutrophil peptide-1 on growth factor and interleukin-8 production by human lung fibroblasts and epithelial cells."], "weko_shared_id": -1}
Differential effects of human neutrophil peptide-1 on growth factor and interleukin-8 production by human lung fibroblasts and epithelial cells.
http://hdl.handle.net/10069/25638
http://hdl.handle.net/10069/25638f4dda73b-3308-4084-af74-937f81fa5ec3
名前 / ファイル | ライセンス | アクション |
---|---|---|
ELR36_411.pdf (2.1 MB)
|
|
Item type | 学術雑誌論文 / Journal Article(1) | |||||
---|---|---|---|---|---|---|
公開日 | 2011-09-01 | |||||
タイトル | ||||||
タイトル | Differential effects of human neutrophil peptide-1 on growth factor and interleukin-8 production by human lung fibroblasts and epithelial cells. | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Epithelial cells | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Fibroblasts | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Human neutrophil peptide-1 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | KEYWORDS α-defensins | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Amenomori, Misato
× Amenomori, Misato× Mukae, Hiroshi× Ishimatsu, Yuji× Sakamoto, Noriho× Kakugawa, Tomoyuki× Hara, Atsuko× Hara, Shintaro× Fujita, Hanako× Ishimoto, Hiroshi× Hayashi, Tomayoshi× Kohno, Shigeru |
|||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | alpha-Defensins, antimicrobial peptides produced mainly by neutrophils, have been reported to be associated with a wide variety of lung diseases, including idiopathic pulmonary fibrosis (IPF), cystic fibrosis (CF), and diffuse panbronchiolitis (DPB). In each disease, alpha-defensins are located in different areas, such as around the alveolar septa in IPF and around the airways in CF and DPB, suggesting that alpha-defensins play different roles. Meanwhile, growth factors are known to contribute to IPF, CF, and DPB. alpha-Defensins are known to induce interleukin (IL)-8 in airway epithelial cells, but the effects of alpha-defensins on the release of growth factors from various components in the lung have not been sufficiently investigated. In the present study, the in vitro effects of human neutrophil peptide (HNP)-1 (a subtype of alpha-defensin) on the expressions of IL-8 and growth factors in lung fibroblasts, bronchial epithelial cells, and alveolar epithelial cells were examined. HNP-1 mainly enhanced the expression of IL-8 in epithelial cells, whereas it enhanced transforming growth factor-beta and vascular endothelial growth factor expressions in lung fibroblasts. These results suggest that alpha-defensins play different roles in the pathogenesis of IPF, CF, and DPB according to the location in the lung where the alpha-defensins are mainly produced. | |||||
書誌情報 |
Experimental Lung Research 巻 36, 号 7, p. 411-419, 発行日 2010-09 |
|||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 01902148 | |||||
EISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 15210499 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA00181680 | |||||
PubMed番号 | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | PMID | |||||
関連識別子 | 20715983 | |||||
DOI | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.3109/01902141003714049 | |||||
権利 | ||||||
権利情報 | © 2010 Informa Healthcare USA, Inc. | |||||
権利 | ||||||
権利情報 | This is an electronic version of an article published in Experimental lung research, 36(7), pp.411-419; 2010. Experimental lung research is available online at: http://informahealthcare.com/doi/abs/10.3109/01902141003714049 | |||||
著者版フラグ | ||||||
出版タイプ | AM | |||||
出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Experimental Lung Research, 36(7), pp.411-419; 2010 |