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早期関節炎の捉え方と病態解析の方向性
http://hdl.handle.net/10069/24072
http://hdl.handle.net/10069/24072f86f3729-6924-46fa-80cb-313a43f2ceaf
名前 / ファイル | ライセンス | アクション |
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JJCI30_37.pdf (276.3 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2010-10-05 | |||||
タイトル | ||||||
タイトル | 早期関節炎の捉え方と病態解析の方向性 | |||||
言語 | ||||||
言語 | jpn | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | rheumatoid arthritis | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | anti-CCP antibody | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | MRI | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | bone marrow edema | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | genetic analysis | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
川上, 純
× 川上, 純× 玉井, 慎美× 江口, 勝美 |
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著者別名 | ||||||
姓名 | Kawakami, Atsushi | |||||
著者別名 | ||||||
姓名 | Tamai, Mami | |||||
著者別名 | ||||||
姓名 | Eguchi, Katsumi | |||||
その他のタイトル | ||||||
その他のタイトル | Classification of early arthritis patients and how to determine disease severity | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | 近年の臨床研究で関節リウマチの予後は早期からの治療介入により改善し,かつ,生物学的製剤の早期治療では約半数の症例で臨床的寛解が得られることが明らかとなった.すなわち関節リウマチの早期診断および早期からの適切な治療法の選択は極めて重要である.私たちは早期関節炎の前向き症例対照研究により,初診時に抗CCP抗体およびMRIでの骨髄浮腫が陽性の早期関節炎は,高率に関節リウマチに進展することを明らかにした.これら臨床的評価に加え遺伝学的解析も含めた早期関節炎の層別化を試みており,これらのデータをもとに早期関節炎の捉え方と病態解析の方向性について述べる. | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Recent clinical studies of rheumatoid arthritis reveal that therapeutic intervention early in rheumatoid arthritis leads to less joint damage, indicating the importance of early diagnosis of RA for improvement of prognosis. According to the data of our “Early Arthritis Prospective Cohort”, we have found that early arthritis patients, described as undifferentiated arthritis, progress to rheumatoid arthritis at high frequency if the patients positive with anti-cyclic citrullinated peptide antibody (anti-CCP antibody) and bone marrow edema at the entry. In addition, we are going to classify the pathologic status (disease severity) of early arthritis patients by serologic variables, radiographic findings and genetic analysis. | |||||
書誌情報 |
日本臨床免疫学会会誌 en : Japanese Journal of Clinical Immunology 巻 30, 号 1, p. 37-40, 発行日 2007-02-28 |
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出版者 | ||||||
出版者 | 日本臨床免疫学会 | |||||
出版者別言語 | ||||||
The Japan Society for Clinical Immunology | ||||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 09114300 | |||||
EISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 13497413 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AN00357971 | |||||
DOI | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.2177/jsci.30.37 | |||||
権利 | ||||||
権利情報 | Copyright (c) 2007 日本臨床免疫学会 | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | 日本臨床免疫学会会誌, 30(1), pp.37-40; 2007 |