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Interestingly, its propargylic derivative, 12-hydroxyoctadec-10-ynoic acid (compound B), \nwhich was obtained as a synthetic intermediate of compound A, showed an even more extensive algicidal activity. In this study, the effects of compound A and B on the major causative species of harmful algal blooms (HABs) such as Chattonella marina (Ochrophyta, Raphidophyceae), Heterocapsa circularisquama, and Karenia mikimotoi \n(Miozoa, Dinophyceae) in addition to C. antiqua were investigated. Both compounds exhibited toxic effects on these red tide flagellates in a concentration dependent manner with LC50 \u003c 10 μg/mL, and the activities of compound B were much stronger than compound A. Zooplankton rotifer (Brachionys plicatilis) was relatively \nresistant to the compounds, and the lethal effects of H. circularisquama and K. mikimotoi on rotifers were reduced in the presence of compound A and B, suggesting their potential usage in the mitigation strategy for HABs. 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Bioactivities of algicidal C18 hydroxy unsaturated fatty acid isolated from the red alga Tricleocarpa jejuensis and its synthesized propargylic derivative
http://hdl.handle.net/10069/40370
http://hdl.handle.net/10069/40370438855ff-0991-44df-a249-f2a4c3b73f91
名前 / ファイル | ライセンス | アクション |
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AR52_102097.pdf (608.6 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2020-12-16 | |||||
タイトル | ||||||
タイトル | Bioactivities of algicidal C18 hydroxy unsaturated fatty acid isolated from the red alga Tricleocarpa jejuensis and its synthesized propargylic derivative | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Algicidal activity | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Antibacterial activity | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | C18 hydroxy unsaturated fatty acid | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Cytotoxicity | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Red tide phytoplankton | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Tricleocarpa jejuensis | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Zha, Shijiao
× Zha, Shijiao× Liang, Yan× Oda, Tatsuya× Ishibashi, Fumito |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | (±)-(E)-12-hydroxyoctadec-10-enoic acid (compound A) was isolated from the red alga Tricleocarpa jejuensis in our previous study as a potent algicidal compound against red tide microalga Chattonella antiqua (Ochrophyta, Raphidophyceae). Interestingly, its propargylic derivative, 12-hydroxyoctadec-10-ynoic acid (compound B), which was obtained as a synthetic intermediate of compound A, showed an even more extensive algicidal activity. In this study, the effects of compound A and B on the major causative species of harmful algal blooms (HABs) such as Chattonella marina (Ochrophyta, Raphidophyceae), Heterocapsa circularisquama, and Karenia mikimotoi (Miozoa, Dinophyceae) in addition to C. antiqua were investigated. Both compounds exhibited toxic effects on these red tide flagellates in a concentration dependent manner with LC50 < 10 μg/mL, and the activities of compound B were much stronger than compound A. Zooplankton rotifer (Brachionys plicatilis) was relatively resistant to the compounds, and the lethal effects of H. circularisquama and K. mikimotoi on rotifers were reduced in the presence of compound A and B, suggesting their potential usage in the mitigation strategy for HABs. Consistent with the toxicities on the HAB species, compound B showed stronger cytotoxicity on HeLa, XC, and U937 cells than A. Since compound B but not compound A showed haemolytic activity on rabbit erythrocytes, specific action of compound B on cell membrane may be responsible for the potent cytotoxicity. Furthermore, compound B exhibited higher antibacterial effect on Staphylococcus aureus than compound A, while both were not effective on Enchiridia coli. Our results suggest that compound A and B are promising multifunctional candidates with potential to develop not only as anti-red tide microalgae but also as tumor cell-killing and antibacterial agents. This is the first report indicating that replacing a double bond in the hydroxy unsaturated fatty acid with a triple bond results in much augmentation of the bioactivities. |
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書誌情報 |
Algal Research 巻 52, p. 102097, 発行日 2020-10-08 |
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出版者 | ||||||
出版者 | Elsevier B.V. | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 22119264 | |||||
DOI | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1016/j.algal.2020.102097 | |||||
権利 | ||||||
権利情報 | c 2020 Elsevier B.V. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/ | |||||
著者版フラグ | ||||||
出版タイプ | AM | |||||
出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Algal Research, 52, art.no.102097; 2020 |